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Background: Persian Medicine (PM) is a classical holistic medical system emphasizing individualized assessment of mizaj (temperament), environmental and lifestyle determinants of health, and sensory-oriented interventions. Contemporary arts-based healing approaches similarly foreground embodiment, emotional regulation, and therapeutic engagement, yet clinical integration models systematically combining PM with arts-in-health remain underexplored.

Objectives: To conceptualize and operationalize an integrative clinical research framework that combines PM with arts-based modalities for chronic and stress-related conditions, and to identify measurable outcomes that support evidence-based care.

Methods: We conducted a structured literature synthesis of PM theory and clinical evidence, mapped theoretical mechanisms shared with arts-in-health (e.g., autonomic regulation, affect modulation), and identified feasible clinical endpoints. Proposed research designs include pilot pragmatic trials and mixed-methods evaluations with both physiological markers (e.g., heart rate variability) and patient-reported outcomes.

Results/Insights: Our framework highlights convergent mechanisms linking PM diagnostic principles with arts-based interventions, suggesting enhanced patient engagement and stress modulation compared to standard care alone. Preliminary case series and pilot data indicate trends toward improved symptom burden and quality of life in conditions such as chronic pain and functional disorders.

Conclusion/Implications: Integrating PM with healing arts offers a culturally grounded, clinically testable model for person-centered care that bridges traditional medical wisdom with contemporary arts-in-health practices. This framework can inform future rigorous clinical research and interdisciplinary programs in integrative health.