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Purpose: To evaluate the efficacy and safety of slow transscleral cyclophotocoagulation (CPC) using a diode laser G-probe and to compare outcomes with micropulse CPC reported in the literature.

Methods: A clinical study (retrospective/prospective) was conducted in patients with refractory glaucoma treated with slow CPC using an 810-nm diode laser (Iridex OcuLight SLx). Laser settings were 1,250 mW with a 4-second duration per application over 180°–270°, sparing the 3 and 9 o’clock meridians. Primary outcomes included intraocular pressure (IOP) reduction and reduction in antiglaucoma medications. Secondary outcomes included postoperative complications. A literature-based comparison with micropulse CPC (MicroPulse G6) was performed.

Results: Slow CPC resulted in a significant and sustained reduction in IOP, along with a decrease in the number of topical medications. Compared with published micropulse CPC outcomes, slow CPC demonstrated greater magnitude and durability of IOP lowering. Postoperative inflammation was more frequent but transient and manageable. No cases of prolonged hypotony, phthisis bulbi, or severe vision loss were observed.

Conclusions: Slow transscleral CPC is an effective and reproducible technique for refractory glaucoma, providing greater IOP reduction than micropulse CPC with an acceptable safety profile when parameters are carefully controlled.