26kgg566 10.3205/26kgg566 urn:nbn:de:0183-26kgg5666 Meeting Abstract Großkinsky Großkinsky Nicole N

NAKO e.V., Wissenschaftliches Projektmanagement, Deutschland

author Memmer Memmer Nicole N

NAKO e.V., Wissenschaftliches Projektmanagement, Deutschland

author Preuß Preuß Stephanie S

NAKO e.V., Wissenschaftliches Projektmanagement, Deutschland

author Palm Palm Lennart L

NAKO e.V., Wissenschaftliches Projektmanagement, Deutschland

author Rodriguez Rodriguez Fransisca-Saveria FS

German Center for Neurodegenerative Diseases, Psychosocial Epidemiology & Public Health, Deutschland

author Jung Jung Matthias M

University of Freiburg, Department of Diagnostic and Interventional Radiology, Medical Center, Faculty of Medicine, Freiburg, Deutschland

author Götz Götz Simon S

Düsseldorf University Hospital, Institute of Medical Sociology, Düsseldorf, Deutschland

author Sprenger-Vukovic Sprenger-Vukovic Alina A

Düsseldorf University Hospital, Institute of Medical Sociology, Düsseldorf, Deutschland

author Breunig Breunig Esther E

German Cancer Research Center (DKFZ), Management-related Controlling, Deutschland

author Lieb Lieb Wolfgang W

Christian-Albrechts-University Kiel, Institute of Epidemiology, Kiel, Deutschland

author Pischon Pischon Tobias T

Max Delbrück Center for Molecular Medicine (MDC), Deutschland

author Schikowski Schikowski Tamara T

IUF, Leibniz Institute for Environmental Medicine, Deutschland

author Peters Peters Annette A

German Research Center for Environmental Health, Helmholtz Zentrum München, Institute of Epidemiology, München, Deutschland

author German Medical Science GMS Publishing House

Düsseldorf

610 20251030 engl This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). M0662 566 Deutsche Gesellschaft für Allgemeinmedizin und Familienmedizin Deutsche Gesellschaft für Sozialmedizin und Prävention Netzwerk Evidenzbasierte Medizin e.V. Deutsche Gesellschaft für Medizinische Soziologie 60. Kongress für Allgemeinmedizin und Familienmedizin Gesundheit gestalten Soziale Determinanten für Gesundheit in der NAKO Göttingen 20260930 20261002 SYM-01-01 TextNames of the moderators and speakers: Chair: Prof. Dr. Tamara SchikowskiSpeakers: F.-S. Rodriguez2, M. Jung3, S. Götz4, A. Sprenger-Vukovic4Background: Social determinants of health such as socioeconomic position, employment status, living arrangements, and gender play a key role in shaping health behaviors, disease risk, and health inequities. Large population-based cohorts with detailed social, psychosocial, and biological data allow robust analyses to explore these relationships. The German National Cohort (NAKO) provides a unique research infrastructure with extensive phenotyping, imaging data, and longitudinal follow-ups to study how social determinants interact with biological and behavioral pathways.Aim/scientific question: This symposium provides an overview how social determinants of health can be studied using NAKO data. Selected research projects highlight the potential of the cohort to analyze associations between socioeconomic, occupational variables and diverse health outcomes.Topic for discussion: The symposium discusses the value of large cohort studies for research on social determinants and health inequities, focusing on integrating (psycho-)social, biological, and imaging data, and the advantages of longitudinal analyses to understand health pathways.Content: NAKO is the largest population-based cohort study in Germany. Between 2014 and 2019, over 205,000 individuals aged 20–74 were recruited at 18 study centers. Participants completed standardized interviews, questionnaires, biomedical assessments, and provided biological samples. A subgroup also underwent whole-body MRI, enabling detailed analyses of body composition and organ characteristics.Follow-ups (FU) occur every ~5 years. The 5-year FU (10/2018–07/2024) included over 138,000 participants (response rate: 67,5%), including >18,000 with a second MRI. The 10-year FU started in June 2024 and aims to re-examine 85,000 participants.The symposium presents study design, methods, and selected results from four projects: 1) associations of low income, unemployment, and living alone with cognitive function; 2) whole-body MRI assessed sex differences in body composition; 3) work-related stress and inflammatory markers (CRP); 4) longitudinal links between working from home and depressive symptoms.Take Home Message: NAKO provides critical insights into the health impact of social, occupational factors and gender. Findings can inform public health strategies and support targeted prevention and health promotion interventions to promote equity. To access NAKO data and biological samples visit: NAKO TransferHub at www.nako.de/transferhub.Competing interests: None 0 0 0 0