26dkou51310.3205/26dkou513urn:nbn:de:0183-26dkou5133Meeting AbstractCERAchange study: Clinical applications of Cerament G & V in periprosthetic infections and two-stage total hip arthroplasty exchangeSimonSimonDominicDMuskuloskelettales Universitätszentrum München (MUM), LMU Klinikum, München, DeutschlandauthorBrucknerBrucknerAlexandraAMuskuloskelettales Universitätszentrum München (MUM), LMU Klinikum, München, DeutschlandauthorKirchhoffKirchhoffKatharinaKMuskuloskelettales Universitätszentrum München (MUM), LMU Klinikum, München, DeutschlandauthorBeckersBeckersGautierGMuskuloskelettales Universitätszentrum München (MUM), LMU Klinikum, München, DeutschlandauthorSueroSueroEduardoEMuskuloskelettales Universitätszentrum München (MUM), LMU Klinikum, München, DeutschlandauthorSchröderSchröderLennartLMuskuloskelettales Universitätszentrum München (MUM), LMU Klinikum, München, DeutschlandauthorCheersCheersGilesGMuskuloskelettales Universitätszentrum München (MUM), LMU Klinikum, München, DeutschlandauthorWieserWieserJosefJMuskuloskelettales Universitätszentrum München (MUM), LMU Klinikum, München, DeutschlandauthorThorwächterThorwächterChristophCMuskuloskelettales Universitätszentrum München (MUM), LMU Klinikum, München, DeutschlandauthorMayerMayerSusanneSMuskuloskelettales Universitätszentrum München (MUM), LMU Klinikum, München, DeutschlandauthorHolzapfelHolzapfelBorisBMuskuloskelettales Universitätszentrum München (MUM), LMU Klinikum, München, DeutschlandauthorGerman Medical Science GMS Publishing House
Düsseldorf
61020261020englThis is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License.Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung).M0659513Deutsche Gesellschaft für Orthopädie und UnfallchirurgieDeutsche Gesellschaft für Orthopädie und Orthopädische ChirurgieDeutsche Gesellschaft für UnfallchirurgieBerufsverband für Orthopädie und UnfallchirurgieDeutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2026)Poster | Septische ChirurgieBerlin2026102020261023DKOU26_Abs_2335TextObjectives and questions: Two-stage exchange remains the gold standard for the treatment of chronic periprosthetic joint infection (PJI). Biodegradable antibiotic carriers such as Cerament® G (gentamicin-loaded) and Cerament® V (vancomycin-loaded) have emerged as potential alternatives to conventional gentamicin and vancomycin-loaded polymethylmethacrylate (PMMA) spacers, offering high local antibiotic concentrations without the need for later removal. This study compares clinical and pharmacokinetic outcomes of Cerament® versus PMMA in two-stage revision arthroplasty.Material and methods: A total of 17 patients undergoing two-stage revision for confirmed PJI were included prospectively up to date. Eight patients received Cerament® G & V, and nine patients were treated with Gentamicin and Vancomycin antibiotic-loaded PMMA. The mean age was 66.3 years; 15 patients were male and 2 female. Preoperative diagnosis of PJI was established by diagnostic hip joint aspiration with pathological synovial fluid cell count and positive microbiological findings. Intraoperative histological analysis confirmed infection in all included cases. Both groups underwent implant explantation followed by placement of either Cerament® or PMMA. A planned interval of six weeks between stages was applied. Reimplantation was performed once infection was clinically and laboratorially controlled. Intravenous antibiotics were administered according to recommendations of the Antibiotic Stewardship (ABS) team, followed by oral antibiotics after discharge until replantation. Total antibiotic therapy duration was planned for 12 weeks. Postoperatively, local concentrations of gentamicin and vancomycin were measured via surgical drains for seven days following explantation, as well as clinical parameters (Table 1 ), furthermore dead space management was evaluated radiologically and histologically (Figure 1 ). Groups were compared using a two-tailed independent samples Student’s t-test.Results: Cerament® V and also G demonstrated sustained high local antibiotic concentrations in the early postoperative period compared to PMMA, with measurable elution over the first seven days. Infection control prior to replantation was achieved. No reinfections occurred within the observed interval in the Cerament® cohort. The biodegradable nature of Cerament® eliminated the need for removal of antibiotic carrier material at replantation, therefore accelerating replantation with reduced blood loss and prevention of mechanical complications of the spacer, such as dislocation or fracture.Discussion and conclusions: In two-stage revision for PJI, Cerament® G and Cerament® V provide effective local antibiotic delivery with sustained postoperative elution and infection control, enabling dead-space management with a bone substitute. Therefore, biodegradable antibiotic carriers may represent a promising alternative in revision arthroplasty, potentially improving local pharmacokinetics while avoiding the limitations of non-resorbable cement spacers.