26rhk197 10.3205/26rhk197 urn:nbn:de:0183-26rhk1971 Meeting Abstract Möbius Möbius Amelie A

Universitätsklinikum Leipzig (UKL) Klinik und Poliklinik für Rheumatologie, Leipzig, Deutschland

author Mühlberg Mühlberg Katja K

Universitätsklinikum Leipzig (UKL) Klinik und Poliklinik für Angiologie, Leipzig, Deutschland

author Seifert Seifert Olga O

Universitätsklinikum Leipzig (UKL) Klinik und Poliklinik für Rheumatologie, Leipzig, Deutschland

author German Medical Science GMS Publishing House

Düsseldorf

610 20260909 engl This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). M0656 197 Deutsche Gesellschaft für Rheumatologie Deutsche Gesellschaft für Orthopädische Rheumatologie Gesellschaft für Kinder- und Jugendrheumatologie 54. Kongress der Deutschen Gesellschaft für Rheumatologie und Klinische Immunologie (DGRh), 36. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR), 40. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh) Deutscher Rheumatologiekongress 2026 Rheumatoide Arthritis Leipzig 20260909 20260912 RA.12 TextIntroduction: Increasing scientific evidence suggests that systemic inflammatory diseases play a central role in the development of arteriosclerosis . To better understand the pathogenesis, it is important to investigate which additional risk factors could contribute to atherosclerosis . In recent years, various candidate genes, genetic polymorphisms and susceptibility loci have been identified that are associated with atherosclerotic diseases . This study aimed to evaluate genetic and clinical predictors of carotid intima media thickness (cIMT) in patients with rheumatoid arthritis (RA).Methods: Out of a cohort of 133 RA patients, we studied typical arteriosclerosis risk factors (age, sex, body-mass-Index (BMI), lipid status, diabetes mellitus, and hypertension) as well as RA disease activity compared to 33 hand osteoarthritis (OA) patients. To evaluate arteriosclerosis, ultrasound examination of brain supplying arteries for determination of plaques was performed, as well as the assessment of cIMT. Genomic DNA of a subgroup of RA patients was extracted from EDTA blood leukocytes to analyse b2-adrenoceptor polymorphism (β2AR-SNPs) at codon positions 16, 27 and 164 .Results: RA patients had a higher prevalence of plaques compare to the controls (34.6% vs. 21.6%). Moderate and high-grade stenosis was observed in 9% RA patients versus 3% OA patients. The mean cIMT was also higher in RA patients (0.992 ± 0.391 mm). Genetic analysis of a subgroup of RA patients revealed a moderate correlation between the Arg16 polymorphism of β2AR and cIMT (Z = –1.956, p = 0.05). In multivariate regression analysis, age (β = 0.374, p = 0.001) and disease activity (DAS28 > 2,6; β = 0.311, p = 0.007) were identified as independent predictors of increased cIMT in RA patients, while BMI, low-density lipoprotein, CRP, RF/Anti-CCP, and radiological erosions showed no significant correlations.Conclusion: Both traditional atherosclerosis risk factors and RA disease activity may contribute to the development of atherosclerosis in RA patients. Additionally, the Arg16 polymorphism of the β2AR was positively associated with cIMT functioning as surrogate of atherosclerotic changes in this patient group. Further studies are warranted to determine the role of genetic factors on arteriosclerosis.Disclosures: AM declares no conflicts of interest. Weber BN Giles JT Liao KP Shared inflammatory pathways of rheumatoid arthritis and atherosclerotic cardiovascular disease 2023 Nat Rev Rheumatol 417-428 Weber BN, Giles JT, Liao KP. Shared inflammatory pathways of rheumatoid arthritis and atherosclerotic cardiovascular disease. Nat Rev Rheumatol. 2023 Jul;19(7):417-428. DOI: 10.1038/s41584-023-00969-7 http://dx.doi.org/10.1038/s41584-023-00969-7 Libby P The changing landscape of atherosclerosis 2021 Nature 524-533 Libby P. The changing landscape of atherosclerosis. Nature. 2021 Apr;592(7855):524-533. DOI: 10.1038/s41586-021-03392-8 https://doi.org/10.1038/s41586-021-03392-8 Metaxa S Missouris C Mavrogianni D Miliou A Oikonomou E Toli E Kormali L Vlismas A Drakakis P Tousoulis D Polymorphism Gln27Glu of β2 Adrenergic Receptors in Patients with Ischaemic Cardiomyopathy 2018 Curr Vasc Pharmacol 618-623 Metaxa S, Missouris C, Mavrogianni D, Miliou A, Oikonomou E, Toli E, Kormali L, Vlismas A, Drakakis P, Tousoulis D. Polymorphism Gln27Glu of β2 Adrenergic Receptors in Patients with Ischaemic Cardiomyopathy. Curr Vasc Pharmacol. 2018;16(6):618-623. DOI: 10.2174/1570161115666170919180959 http://dx.doi.org/10.2174/1570161115666170919180959 Malysheva O Pierer M Wagner U Wahle M Wagner U Baerwald CG Association between beta2 adrenergic receptor polymorphisms and rheumatoid arthritis in conjunction with human leukocyte antigen (HLA)-DRB1 shared epitope 2008 Ann Rheum Dis 1759-64 Malysheva O, Pierer M, Wagner U, Wahle M, Wagner U, Baerwald CG. Association between beta2 adrenergic receptor polymorphisms and rheumatoid arthritis in conjunction with human leukocyte antigen (HLA)-DRB1 shared epitope. Ann Rheum Dis. 2008 Dec;67(12):1759-64. DOI: 10.1136/ard.2007.083782 http://dx.doi.org/10.1136/ard.2007.083782 0 0 0 0