26doc024 10.3205/26doc024 urn:nbn:de:0183-26doc0243 Meeting Abstract Grisanti Grisanti Salvatore S

Klinik für Augenheilkunde, Universität zu Lübeck, Lübeck

author Hattenbach Hattenbach Lars-Olof LO

Klinikum Ludwigshafen, Ludwigshafen am Rhein, Ludwigshafen

author Muqit Muqit Mahi M

Moorfields Eye Hospital, London, Vereinigtes Königreich

author Le Mer Le Mer Yannick Y

Hôpital Fondation A. de Rothschild, Department of Ophthalmology, Paris, Frankreich

author Cusumano Cusumano Andreas A

University of Rome, Department of Experimental Medicine, Rom, Italien

author Sahel Sahel José-Alain JA

University of Pittsburgh, Department of Ophthalmology, Pittsburgh, USA

author Stanzel Stanzel Boris V. BV

Knappschaft Klinikum Saar, Augenklinik Sulzbach, Sulzbach

author Szurman Szurman Peter P

Knappschaft Klinikum Saar, Augenklinik Sulzbach, Sulzbach

author Bartz-Schmidt Bartz-Schmidt Karl U. KU

Eye Hospital Tübingen, Department of Ophthalmology, Tübingen

author Eter Eter Nicole N

Universitätsklinikum Münster, Medical Center, Department of Ophthalmology, Münster

author Wolf Wolf Armin A

Universitätsklinikum Ulm, Klinik für Augenheilkunde, Klinikbereich Michelsberg, Ulm

author Brodie Brodie Frank F

University of California, Ophthalmology, San Francisco, CA, USA

author Hornig Hornig Ralf R

Science Corporation, Alameda, CA, USA

author Holz Holz Frank G. FG

University of Bonn, Department of Ophthalmology, Bonn

author German Medical Science GMS Publishing House

Düsseldorf

610 20260617 engl This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). M0651 024 38. Internationaler Kongress der Deutschen Ophthalmochirurgie (DOC) Retina I Nürnberg 20260618 20260620 FP 3.3 TextObjectives: The PRIMAvera pivotal trial demonstrated that the subretinal photovoltaic PRIMA implant can restore formed vision in patients with advanced geographic atrophy. This substudy aims to characterize multimodal retinal imaging features relevant for patient selection and to evaluate longitudinal structural retinal changes following subretinal implantation of the PRIMA device in geographic atrophy secondary to age-related macular degeneration.Methods: Multimodal retinal imaging included spectral-domain optical coherence tomography (SD-OCT), fundus autofluorescence (FAF), color fundus photography (CFP), and fluorescein angiography (FA). Imaging was performed at baseline and at 4 weeks, as well as at 3, 6, 9, and 12 months postoperatively. Analyses focused on retinal architecture overlying the implant, implant positioning, and postoperative structural changes. Quantitative FAF analysis was conducted to assess longitudinal changes in atrophic lesion size.Results: Thirty-eight implanted eyes were included. Baseline imaging confirmed advanced geographic atrophy with relative preservation of inner retinal layers within the intended implantation area. Multimodal imaging demonstrated that subretinal placement of the implant over the retinal pigment epithelium did not result in significant alterations of the inner retinal architecture, with no evidence of progressive inner retinal thinning over 12 months. Postoperatively, a low incidence of complications was observed, including macular hole formation in 4/38 eyes and choroidal neovascularization in 2/38 eyes. As expected, FAF imaging revealed variable degrees of atrophic changes related to subretinal surgical delivery. Overall, these imaging findings provide valuable insights for postoperative assessment and management of patients receiving the PRIMA implant.Conclusions: Multimodal imaging demonstrates preservation of inner retinal structure following subretinal PRIMA implantation and offers important guidance for both patient selection and postoperative monitoring. 0 0 0 0