25dga191 10.3205/25dga191 urn:nbn:de:0183-25dga1917 Meeting Abstract Schüller Schüller Alina A

Friedrich-Alexander-Universität Erlangen-Nürnberg, Department Artificial Intelligence in Biomedical Engineering, Erlangen, Deutschland

author Schilling Schilling Achim A

Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Deutschland

author Krauss Krauss Patrick P

Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Deutschland

author Rampp Rampp Stefan S

Universitätsklinikum Erlangen, Department of Neurosurgery, Erlangen, Deutschland

author Reichenbach Reichenbach Tobias T

Friedrich-Alexander-Universität Erlangen-Nürnberg, Department Artificial Intelligence in Biomedical Engineering, Erlangen, Deutschland

author German Medical Science GMS Publishing House

Düsseldorf

610 20250318 engl This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). M0607 191 Deutsche Gesellschaft für Audiologie e. V. und ADANO 27. Jahrestagung der Deutschen Gesellschaft für Audiologie und Arbeitstagung der Arbeitsgemeinschaft Deutschsprachiger Audiologen, Neurootologen und Otologen Postersession Göttingen 20250319 20250321 191 TextSelective attention enables individuals to prioritize relevant auditory information while suppressing competing distractions, facilitating tasks like understanding a single speaker in a crowded environment. The neural mechanisms of selective attention to speech have predominantly been studied through low-frequency brain responses in the auditory cortex, linked to the rhythms of phonemes, syllables, and words. However, emerging evidence from EEG studies indicates that selective attention also modulates subcortical neural responses , , specifically the speech frequency-following response (speech-FFR), which reflects neural encoding of the fundamental frequency of speech and its harmonics. While recent Magnetoencephalography (MEG) studies have identified cortical contributions to the speech-FFR , , , it remains unclear whether these cortical contributions are similarly influenced by selective attention.In this study, we utilized MEG and subsequent source reconstruction to investigate how selective attention modulates cortical contributions to the speech-FFR. MEG data were recorded from 22 healthy, normal-hearing participants while they listened to continuous speech stimuli from two competing male speakers over 40 minutes. Participants were instructed to alternate their attention between the two speakers at regular intervals . To analyze the data, we computed neural responses at the fundamental frequency using neural source estimation and source-level temporal response functions (TRFs). We then compared the cortical speech-FFR for each speaker when they were supposed to be attended versus ignored.Our findings demonstrated a robust effect of selective attention on cortical contributions to the speech-FFR. Neural responses to the fundamental frequency of the target speaker were significantly enhanced compared to the distractor speaker. This attentional modulation was observed consistently across both the group and individual participant levels. Moreover, independent of attentional focus, the speaker with a lower fundamental frequency elicited stronger cortical contributions to the speech-FFR compared to the speaker with a higher fundamental frequency. These results expand upon previous work by showing that selective attention modulates not only subcortical but also cortical components of the speech-FFR, emphasizing the dynamic interplay between attention and the neural encoding of speech. This study provides novel insights into how cortical mechanisms support selective attention in complex auditory environments and has recently been published in the Journal of Neuroscience . Forte AE Etard O Reichenbach T The human auditory brainstem response to running speech reveals a subcortical mechanism for selective attention 2017 Elife e27203 Forte AE, Etard O, Reichenbach T. The human auditory brainstem response to running speech reveals a subcortical mechanism for selective attention. Elife. 2017 Oct 10;6:e27203. DOI: 10.7554/eLife.27203 http://dx.doi.org/10.7554/eLife.27203 Etard O Kegler M Braiman C Forte AE Reichenbach T Decoding of selective attention to continuous speech from the human auditory brainstem response 2019 Neuroimage 1-11 Etard O, Kegler M, Braiman C, Forte AE, Reichenbach T. Decoding of selective attention to continuous speech from the human auditory brainstem response. Neuroimage. 2019 Oct 15;200:1-11. DOI: 10.1016/j.neuroimage.2019.06.029 http://dx.doi.org/10.1016/j.neuroimage.2019.06.029 Coffey EBJ Chepesiuk AMP Herholz SC Baillet S Zatorre RJ Neural Correlates of Early Sound Encoding and their Relationship to Speech-in-Noise Perception 2017 Front Neurosci 479 Coffey EBJ, Chepesiuk AMP, Herholz SC, Baillet S, Zatorre RJ. Neural Correlates of Early Sound Encoding and their Relationship to Speech-in-Noise Perception. Front Neurosci. 2017 Aug 25;11:479. DOI: 10.3389/fnins.2017.00479 http://dx.doi.org/10.3389/fnins.2017.00479 Kulasingham JP Brodbeck C Presacco A Kuchinsky SE Anderson S Simon JZ High gamma cortical processing of continuous speech in younger and older listeners 2020 Neuroimage 117291 Kulasingham JP, Brodbeck C, Presacco A, Kuchinsky SE, Anderson S, Simon JZ. High gamma cortical processing of continuous speech in younger and older listeners. Neuroimage. 2020 Nov 15;222:117291. DOI: 10.1016/j.neuroimage.2020.117291 http://dx.doi.org/10.1016/j.neuroimage.2020.117291 Schüller A Schilling A Krauss P Reichenbach T The Early Subcortical Response at the Fundamental Frequency of Speech Is Temporally Separated from Later Cortical Contributions 2024 J Cogn Neurosci 475-491 Schüller A, Schilling A, Krauss P, Reichenbach T. The Early Subcortical Response at the Fundamental Frequency of Speech Is Temporally Separated from Later Cortical Contributions. J Cogn Neurosci. 2024 Mar 1;36(3):475-491. DOI: 10.1162/jocn_a_02103 https://doi.org/10.1162/jocn_a_02103 Schüller A Schilling A Krauss P Rampp S Reichenbach T Attentional Modulation of the Cortical Contribution to the Frequency-Following Response Evoked by Continuous Speech 2023 J Neurosci 7429-40 Schüller A, Schilling A, Krauss P, Rampp S, Reichenbach T. Attentional Modulation of the Cortical Contribution to the Frequency-Following Response Evoked by Continuous Speech. J Neurosci. 2023 Nov 1;43(44):7429-40. DOI: 10.1523/JNEUROSCI.1247-23.2023 http://dx.doi.org/10.1523/JNEUROSCI.1247-23.2023 0 0 0 0