25premus094 10.3205/25premus094 urn:nbn:de:0183-25premus0944 Meeting Abstract Tabatabaeifar Tabatabaeifar Sorosh S

Danish Ramazzini Centre, Department of Occupational Medicine, Aarhus University Hospital, Aarhus, Denmark Centre for Integrated Register-Based Research (CIRRAU), Aarhus University, Aarhus, Denmark

author Dalbøge Dalbøge Annett A

Danish Ramazzini Centre, Department of Occupational Medicine, Aarhus University Hospital, Aarhus, Denmark Department of Clinical Medicine, Aarhus University, Aarhus, Denmark

author German Medical Science GMS Publishing House

Düsseldorf

610 20250909 engl This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). M0625 094 12th International Scientific Conference on the Prevention of Work-Related Musculoskeletal Disorders PREMUS 2025 Oral PS 20 Tübingen 20250909 20250912 094 TextIntroduction: The aim was to examine exposure-response relations between occupational hand exposures and carpal tunnel syndrome (CTS), and to compare the relation between surgery and non-surgery treated CTS. The secondary aim was to study sex-specific differences in exposure-response relations.Methods: We conducted a nationwide register-based cohort study of all persons born in Denmark (1945–1994). During follow-up (2010–2013), we identified first-time events of CTS. Occupational hand exposure estimates the year before each follow-up year were obtained by linking individual occupational codes with a job exposure matrix. We used multivariable logistic regression equivalent to discrete survival analysis based on sex and surgery. The excess fraction of cases was calculated. Results: Among roughly 2.4 million persons, we identified 12,374 CTS diagnoses (4,519 among men and 7,855 among women). For both sexes, exposure-response relations were found for all occupational hand exposures. Among men, we found ORadj of 3.6 (95% CI 3.2-3.8) for hand-related force, 2.9 (95% CI 2.5-3.2) for repetitive hand movements, 3.8 (95% CI 2.7-5.2) for non-neutral hand posture, and 2.5 (95% CI 2.2-2.7) for hand-arm vibration in the highest exposure groups. For combined exposure (hand load), ORadj was 3.5 (95% CI 3.1-4.0). Slightly higher ORsadj were generally found for surgery-treated CTS compared to non-surgery treated CTS for both sexes. When comparing sex, somewhat higher ORsadj were found among men. The excess fraction was 49% among men, 38% among women. Discussion: Occupational hand exposures carried a 3-5 fold increased risk of CTS with slightly higher risks for surgery treated compared to non-surgery treated CTS. Even though CTS occurs more frequent among women, somewhat higher exposure-response relations were found for men compared to women. In absolute terms, the number of cases potentially preventable is higher for women, due to a higher number of cases.Conclusion: In the general working population, a substantial fraction of first-time CTS could be related to occupational hand exposures. 0 0 0 0