25premus068 10.3205/25premus068 urn:nbn:de:0183-25premus0681 Meeting Abstract Arent Arent Amalie Hedegaard AH

Aarhus University Hospital, Department of Occupational and Environmental Medicine, Aarhus, Denmark

author Tabatabaeifar Tabatabaeifar Sorosh S

Aarhus University Hospital, Department of Occupational and Environmental Medicine, Aarhus, Denmark

author Dalbøge Dalbøge Annett A

Aarhus University Hospital, Department of Occupational and Environmental Medicine, Aarhus, Denmark

author German Medical Science GMS Publishing House

Düsseldorf

610 20250909 engl This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). M0625 068 12th International Scientific Conference on the Prevention of Work-Related Musculoskeletal Disorders PREMUS 2025 Oral PS 13 Tübingen 20250909 20250912 068 TextIntroduction: We previously found that one-year occupational mechanical hand exposure increases the risk of carpal tunnel syndrome (CTS). However, only a few studies have investigated the effects of cumulative exposure. This study aimed to examine the association between three-years of cumulative occupational mechanical hand exposure and the risk of CTS, with a focus on identifying exposure-response relationships.Methods: This nationwide cohort study included 1,147,597 women and 1,189,205 men born in Denmark between 1945 and 1994 identified through national registers. During the follow-up (2010–2013), 12,343 patients with CTS were identified. Occupational mechanical exposures (i.e., forceful movements, repetitive movements, non-neutral postures, hand-arm vibrations, and combined hand exposures (hand load)) were assessed by linking DISCO-08 job codes with a hand-specific job exposure matrix. Associations were estimated using multivariate logistic regression. Both surgically and non-surgically treated CTS cases were analyzed.Results: The overall incidence rate was nearly twice as high in women than in men. For both sexes, clear exposure-response relationships were observed for all occupational mechanical exposures. Among women, the highest adjusted odds ratios (ORsadj) were found in those exposed to the highest category of non-neutral hand postures and combined hand load; ORadj 2.6 (95% CI 2.4-2.9) and 3.0 (95% CI 2.6-3.4), respectively. Among men, the highest ORsadj were found for forceful movements, with an OR of 3.4 (95% CI 3.0-3.7) and combined hand load, with an ORadj of 3.2 (95% CI 2.8-3.7). ORsadj was generally higher in surgically treated cases than in nonsurgical cases.Discussion: Our results corroborate those of previous research by reinforcing the role of occupational mechanical hand exposure as a risk factor for CTS. Importantly, the findings emphasize that assessing exposure limited to the year immediately preceding the diagnosis may be inadequate. A more comprehensive understanding of CTS etiology requires consideration of cumulative hand exposure up to three-year before diagnosis.Conclusion: Over a three-year period, cumulative occupational mechanical hand exposure was significantly associated with an elevated risk of CTS, particularly among males and those undergoing surgical intervention. Tabatabaeifar S Dalbøge A Carpal tunnel syndrome and occupational hand exposures: a Danish nationwide cohort study 2024 Occup Environ Med 417-24 Tabatabaeifar S, Dalbøge A. Carpal tunnel syndrome and occupational hand exposures: a Danish nationwide cohort study. Occup Environ Med. 2024 Aug 29;81(8):417-24. DOI: 10.1136/oemed-2024-109568 http://dx.doi.org/10.1136/oemed-2024-109568 0 0 0 0