Hip and knee periprosthetic joint infection (PJI) – a long-term threat to patients’ quality of life

25dkou206 10.3205/25dkou206 urn:nbn:de:0183-25dkou2068 Meeting Abstract Hip and knee periprosthetic joint infection (PJI) – a long-term threat to patients’ quality of life Hansberg Hansberg Jobst Leopold JL

Center for Musculoskeletal Surgery, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Deutschland

author Goumenos Goumenos Stavros S

author Pidgaiska Pidgaiska Olga O

author Reinecke Reinecke Pia P

author Stöckle Stöckle Ulrich U

author Perka Perka Carsten C author Meller Meller Sebastian S author German Medical Science GMS Publishing House

Düsseldorf

610 20251031 engl This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). M0634 206 Deutsche Gesellschaft für Orthopädie und Unfallchirurgie Deutsche Gesellschaft für Orthopädie und Orthopädische Chirurgie Deutsche Gesellschaft für Unfallchirurgie Berufsverband für Orthopädie und Unfallchirurgie Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2025) Poster | Infektionen Berlin 20251028 20251031 AB29-4382 TextObjectives and questions: The aim of this study was to assess the impact of periprosthetic joint infection (PJI) in the hip and knee on patients' quality of life using patient-reported outcome measures (PROMs) following successful surgical treatment.Material and methods: We included 106 patients with clinically confirmed PJI who underwent at least one septic revision surgery (DAIR, one-stage or two-stage implant exchange revision, or arthrodesis) for hip (n=73) or knee (n=33) arthroplasty between January 1, 2021, and December 31, 2021. Quality of life was assessed using the EQ5D outcome instrument and compared to age-matched normative national data. Hip functionality was evaluated using the modified Harris Hip Score for patients undergoing two-stage hip revision surgery.Results: We successfully interviewed 50 patients (40 hip, 10 knee). None exhibited signs of reinfection. Mortality rates were 8.22% (6/73) in the hip group and 18.18% (6/33) in the knee group. At a mean follow-up of 32.47 ± 3.12 months (min. = 26.87; max. = 38,37), the mean EQ5D index was 0.65 ± 0.31, with an EQ5D-VAS rating of 57.46 ± 20.84, compared to age-matched German normative scores of 0.891 (p < 0.001) and 68.6 ± 1.1 (p < 0.001), and reported scores for patients after primary total hip arthroplasty (THA) of 0.94 ± 0.10 and 76.36 ± 24.03. There was no significant difference between hip (n=40) and knee (n=10) patients in EQ5D index scores (0.66 ± 0.29; 0.6 ± 0.38; p= 0.583) or VAS scores (47.45 ± 21.23; 47.5 ± 20.31; p=0.995). Patients exhibited increased limitations in every subdimension of the EQ5D. In total, 72% of patients reported problems with mobility (compared to 15.9% of the German reference population), 46% with self-care (compared to 2.7%), 72% with usual activities (versus 9.9%), 80% with pain or discomfort (versus 27.6%), and 50% with anxiety or depression (versus 4.3%). The mean modified Hip Score at a mean follow-up of 33.67 ± 3.4 months was 56.53 ± 24, indicating poor functional outcome, compared to age-matched normative values of 93.06 and reported scores after elective primary THA of 91.99 ± 9.40.Discussion and conclusions: Even years after successful surgical eradication of periprosthetic joint infection, patients experience significantly reduced quality of life compared to the reference population. Further clinical studies should evaluate the long-term physical and psychological symptom burden on PJI patients using PROMs. 0 0 0 0