25rhk209 10.3205/25rhk209 urn:nbn:de:0183-25rhk2091 Meeting Abstract Murray Murray Antoine A

MVZ Hochsauerland, Rheumatologie, Arnsberg Medizinische Hochschule Hannover (MHH), Klinik für Immunologie und Rheumatologie, Hannover

author Gaedicke Gaedicke Liane L

Medizinische Hochschule Hannover (MHH), Klinik für Immunologie und Rheumatologie, Hannover

author Zehrfeld Zehrfeld Nadine N

Medizinische Hochschule Hannover (MHH), Klinik für Immunologie und Rheumatologie, Hannover

author Anna C Anna C Müller-Vahl MV

Medizinische Hochschule Hannover (MHH), Klinik für Immunologie und Rheumatologie, Hannover

author Franziska Franziska Tapken T

Medizinische Hochschule Hannover (MHH), Klinik für Immunologie und Rheumatologie, Hannover

author Benz Benz Sabrina S

LMU-München, Division of Clinical Psychology and Psychological Treatment, München

author Witte Witte Torsten T

Medizinische Hochschule Hannover (MHH), Klinik für Immunologie und Rheumatologie, Hannover

author Skripuletz Skripuletz Thomas T

Department of Neurology MHH, Medizinische Hochschule Hannover

author Seeliger Seeliger Tabea T

Department of Neurology MHH, Medizinische Hochschule Hannover

author Ernst Ernst Diana D

Medizinische Hochschule Hannover (MHH), Klinik für Immunologie und Rheumatologie, Hannover

author German Medical Science GMS Publishing House

Düsseldorf

610 20250917 engl This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). M0627 209 Deutsche Gesellschaft für Rheumatologie Deutsche Gesellschaft für Orthopädische Rheumatologie 53. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 39. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh) Deutscher Rheumatologiekongress 2025 Vaskulitiden & Kollagenosen Wiesbaden 20250917 20250920 VK.62 TextIntroduction: Sjögren’s disease (SjD) is a chronic inflammatory autoimmune disease. Whilst the disease usually affects the lachrymal and salivary glands, manifestations of other organ systems can also occur. An association between SjD and autoimmune thyroiditis has already been established, very few publications exist regarding the association of other autoimmune diseases and SjD. This study analyses the prevalence of other coexisting autoimmune diseases and their association with SjD disease activity and antibody status.Methods: A retrospective assessment of 583/625 patients from the Hannover cohort with confirmed SjD diagnosis was performed. Table 1 shows a summary of the patient characteristics. Data were collected from hospital medical records and analysed for evidence of other autoimmune diseases (Figure 1 ).Results: 346/583 (59.3%) of SjD patients had one or more additional autoimmune diseases. The most frequent coexisting autoimmune disease remained autoimmune thyroiditis, occurring in 110/583 (18.9%) patients. Although no clear epidemiological data for autoimmune thyroiditis in the general population in Germany exist, countries sharing similar demographics have been assessed with a prevalence of 1.7–8.5% , . Other autoimmune diseases such as inflammatory bowel disease 16/583 (2.7%) und autoimmune hepatitis 8/583 (1,4%) occurred more frequently in our SjD cohort than in the general German population. Immunodeficiencies were much more common amongst our patient cohort compared to the general German population with 8/583 (1.4%) . We also examined the autoimmune neurological disease multiple sclerosis (MS) 22/583 (3.8%) which occurred more frequently in our SjD cohort than in the general German population . The prevalence of all analysed autoimmune diseases in our patient cohort is summarised in Figure 1 . The other rheumatic diseases which occurred after SjD was already diagnosed are summarised in Table 2 . Coexisting autoimmune diseases were associated with higher ESSDAI Score.Conclusion: Coexisting autoimmune diseases are common in patients with SjD and some autoimmune diseases have a higher prevalence in SjD patients compared to the general population. As SjD is associated with a broad range of symptoms which can be similar to other autoimmune diseases, it is important to also consider if a SjD patient is also suffering from a coexisting autoimmune disease. We plan to analyse the whole Hannover cohort to further investigate the association of SjD and other autoimmune diseases.Disclosures: AM: received honoraria for lectures and travel grants from Abbvie, Boehringer Ingelheim, Novartis, Lilly, Galapagos, Pfizer and has participated in advisory boards for Abbvie, UCB and Rheuma Buddy.LG: none declaredACMV: none declaredNZ: received research grants by Novartis and financial support for conference attendance by Abbvie.FT: none declared SB: none declaredThS: reports honoraria for lectures and travel grants from Alexion, Alnylam Pharmaceuticals, argenx, Bayer Vital, Biogen, Bristol Myers Squibb, Celegne, Centogene, CSL Behring, Euroimmun, Grifols, Hexal AG, Janssen-Cilag, Merck Serone, Novartis, Pfizer, Roche, Sanofi, Siemens, Sobi, Teva, Viatris. His research is supported by the German Ministry for Education and Research (BMBF: CurePML01EN2302), Bristol-Myers Squibb Foundation for Immuno-Oncology (FA 19-010), Claudia von Schilling Foundation for Breast Cancer Research, Else Kröner Fresenius Foundation, Hannover Biomedical Research School (HBRS), Alnylam Pharmaceuticals, CSL Behring, Novartis, Sanofi Genzyme, VHV Foundation.TW: received honoria for lectures by Abbvie, BMS, Chugai, Galapagos, Janssen, Lilly, Pfizer, UCB and Roche. Torsten Witte received funding from the DFG (German Research Foundation) under Germany´s Excellence Strategy – EXC 2155 – project number 390874280.TSe: Received a research grant by Novartis Pharma GmbH and received financial support for a conference attendance by Abbvie.DE: received presentation honoria from Abbvie, Amgen, BMS, Chugai, Cilag-Janssen, Galapagos, GSK, Medac, Lilly, Pfizer, Novartis and Roche., Diana Ernst participated in advisory boards for Abbvie, Galapagos, Amgen and Novartis. Diana Ernst received research grants by Novartis and Abbvie. McLeod DS Cooper DS The incidence and prevalence of thyroid autoimmunity 2012 Endocrine 252-65 McLeod DS, Cooper DS. The incidence and prevalence of thyroid autoimmunity. Endocrine. 2012 Oct;42(2):252-65. DOI: 10.1007/s12020-012-9703-2 http://dx.doi.org/10.1007/s12020-012-9703-2 Wémeau JL Klein M Sadoul JL Briet C Vélayoudom-Céphise FL Graves' disease: Introduction, epidemiology, endogenous and environmental pathogenic factors 2018 Ann Endocrinol (Paris) 599-607 Wémeau JL, Klein M, Sadoul JL, Briet C, Vélayoudom-Céphise FL. Graves' disease: Introduction, epidemiology, endogenous and environmental pathogenic factors. Ann Endocrinol (Paris). 2018 Dec;79(6):599-607. DOI: 10.1016/j.ando.2018.09.002 http://dx.doi.org/10.1016/j.ando.2018.09.002 Stallmach A Atreya R Grunert PC Stallhofer J de Laffolie J Schmidt C Treatment Strategies in Inflammatory Bowel Diseases 2023 Dtsch Arztebl Int 768-78 Stallmach A, Atreya R, Grunert PC, Stallhofer J, de Laffolie J, Schmidt C. Treatment Strategies in Inflammatory Bowel Diseases. Dtsch Arztebl Int. 2023 Nov 10;120(45):768-78. DOI: 10.3238/arztebl.m2023.0142 http://dx.doi.org/10.3238/arztebl.m2023.0142 Sebode M Kloppenburg A Aigner A Lohse AW Schramm C Linder R Population-based study of autoimmune hepatitis and primary biliary cholangitis in Germany: rising prevalences based on ICD codes, yet deficits in medical treatment 2020 Z Gastroenterol 431-8 Sebode M, Kloppenburg A, Aigner A, Lohse AW, Schramm C, Linder R. Population-based study of autoimmune hepatitis and primary biliary cholangitis in Germany: rising prevalences based on ICD codes, yet deficits in medical treatment. Z Gastroenterol. 2020 May;58(5):431-8. English. DOI: 10.1055/a-1135-9306 http://dx.doi.org/10.1055/a-1135-9306 El-Helou SM Biegner AK Bode S Ehl SR Heeg M Maccari ME Ritterbusch H Speckmann C Rusch S Scheible R Warnatz K Atschekzei F Beider R Ernst D Gerschmann S Jablonka A Mielke G Schmidt RE Schürmann G Sogkas G Baumann UH Klemann C Viemann D von Bernuth H Krüger R Hanitsch LG Scheibenbogen CM Wittke K Albert MH Eichinger A Hauck F Klein C Rack-Hoch A Sollinger FM Avila A Borte M Borte S Fasshauer M Hauenherm A Kellner N Müller AH Ülzen A Bader P Bakhtiar S Lee JY Heß U Schubert R Wölke S Zielen S Ghosh S Laws HJ Neubert J Oommen PT Hönig M Schulz A Steinmann S Schwarz K Dückers G Lamers B Langemeyer V Niehues T Shai S Graf D Müglich C Schmalzing MT Schwaneck EC Tony HP Dirks J Haase G Liese JG Morbach H Foell D Hellige A Wittkowski H Masjosthusmann K Mohr M Geberzahn L Hedrich CM Müller C Rösen-Wolff A Roesler J Zimmermann A Behrends U Rieber N Schauer U Handgretinger R Holzer U Henes J Kanz L Boesecke C Rockstroh JK Schwarze-Zander C Wasmuth JC Dilloo D Hülsmann B Schönberger S Schreiber S Zeuner R Ankermann T von Bismarck P Huppertz HI Kaiser-Labusch P Greil J Jakoby D Kulozik AE Metzler M Naumann-Bartsch N Sobik B Graf N Heine S Kobbe R Lehmberg K Müller I Herrmann F Horneff G Klein A Peitz J Schmidt N Bielack S Groß-Wieltsch U Classen CF Klasen J Deutz P Kamitz D Lassay L Tenbrock K Wagner N Bernbeck B Brummel B Lara-Villacanas E Münstermann E Schneider DT Tietsch N Westkemper M Weiß M Kramm C Kühnle I Kullmann S Girschick H Specker C Vinnemeier-Laubenthal E Haenicke H Schulz C Schweigerer L Müller TG Stiefel M Belohradsky BH Soetedjo V Kindle G Grimbacher B The German National Registry of Primary Immunodeficiencies (2012-2017) 2019 Front Immunol 1272 El-Helou SM, Biegner AK, Bode S, Ehl SR, Heeg M, Maccari ME, Ritterbusch H, Speckmann C, Rusch S, Scheible R, Warnatz K, Atschekzei F, Beider R, Ernst D, Gerschmann S, Jablonka A, Mielke G, Schmidt RE, Schürmann G, Sogkas G, Baumann UH, Klemann C, Viemann D, von Bernuth H, Krüger R, Hanitsch LG, Scheibenbogen CM, Wittke K, Albert MH, Eichinger A, Hauck F, Klein C, Rack-Hoch A, Sollinger FM, Avila A, Borte M, Borte S, Fasshauer M, Hauenherm A, Kellner N, Müller AH, Ülzen A, Bader P, Bakhtiar S, Lee JY, Heß U, Schubert R, Wölke S, Zielen S, Ghosh S, Laws HJ, Neubert J, Oommen PT, Hönig M, Schulz A, Steinmann S, Schwarz K, Dückers G, Lamers B, Langemeyer V, Niehues T, Shai S, Graf D, Müglich C, Schmalzing MT, Schwaneck EC, Tony HP, Dirks J, Haase G, Liese JG, Morbach H, Foell D, Hellige A, Wittkowski H, Masjosthusmann K, Mohr M, Geberzahn L, Hedrich CM, Müller C, Rösen-Wolff A, Roesler J, Zimmermann A, Behrends U, Rieber N, Schauer U, Handgretinger R, Holzer U, Henes J, Kanz L, Boesecke C, Rockstroh JK, Schwarze-Zander C, Wasmuth JC, Dilloo D, Hülsmann B, Schönberger S, Schreiber S, Zeuner R, Ankermann T, von Bismarck P, Huppertz HI, Kaiser-Labusch P, Greil J, Jakoby D, Kulozik AE, Metzler M, Naumann-Bartsch N, Sobik B, Graf N, Heine S, Kobbe R, Lehmberg K, Müller I, Herrmann F, Horneff G, Klein A, Peitz J, Schmidt N, Bielack S, Groß-Wieltsch U, Classen CF, Klasen J, Deutz P, Kamitz D, Lassay L, Tenbrock K, Wagner N, Bernbeck B, Brummel B, Lara-Villacanas E, Münstermann E, Schneider DT, Tietsch N, Westkemper M, Weiß M, Kramm C, Kühnle I, Kullmann S, Girschick H, Specker C, Vinnemeier-Laubenthal E, Haenicke H, Schulz C, Schweigerer L, Müller TG, Stiefel M, Belohradsky BH, Soetedjo V, Kindle G, Grimbacher B. The German National Registry of Primary Immunodeficiencies (2012-2017). Front Immunol. 2019 Jul 19;10:1272. DOI: 10.3389/fimmu.2019.01272 http://dx.doi.org/10.3389/fimmu.2019.01272 Korsukewitz C Mäurer M Wiendl H MS-Versorgung heute und Vision für die Zukunft - eine Rolle für die ASV? NeuroTransmitter 2022 Korsukewitz C, Mäurer M, Wiendl H. MS-Versorgung heute und Vision für die Zukunft - eine Rolle für die ASV? NeuroTransmitter. 2022;33(12):32–7. 11

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