25rhk025 10.3205/25rhk025 urn:nbn:de:0183-25rhk0253 Meeting Abstract Sex-specific differences in phenotype and gene expression in psoriasis and psoriatic arthritis patients Gaidies Gaidies Tim T
University Medical Center of the Johannes Gutenberg University, Department of Internal Medicine I, Division of Rheumatology and Clinical Immunology, Mainz
author Boegel Boegel Sebastian S
St. Marienwörth, Bad Kreuznach
author Möckel Möckel Tamara T
University Medical Center of the Johannes Gutenberg University, Department of Internal Medicine I, Division of Rheumatology and Clinical Immunology, Mainz
author Wierczeiko Wierczeiko Anna A
University Medical Center of the Johannes Gutenberg University, Department of Internal Medicine I, Division of Rheumatology and Clinical Immunology, Mainz
author Schwarting Schwarting Andreas A
University Medical Center of the Johannes Gutenberg University, Department of Internal Medicine I, Division of Rheumatology and Clinical Immunology, Mainz Rheumatology Center Rhineland Palatinate, Bad Kreuznach
author German Medical Science GMS Publishing House
Düsseldorf
 610 20250917 engl This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). M0627 025 Deutsche Gesellschaft für Rheumatologie Deutsche Gesellschaft für Orthopädische Rheumatologie 53. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 39. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh) Deutscher Rheumatologiekongress 2025 Experimentelle & Translationale Rheumatologie Wiesbaden 20250917 20250920 ET.04 TextIntroduction: Psoriatic arthritis (PSA) is a progressive inflammatory arthritis of the joints and entheses. The symptoms manifest with a large variety e.g., dactylitis, monarthritis, polyarthritis, spondylitis, with or without Psoriasis (PSO) (10%), resulting in joint destruction and disability in severe cases. Knowledge of the differences in clinical manifestation and underlying altered gene expression between genders and disease entities is important for early diagnosis and treatment success (Tannarum et al. ) but is often lacking.Methods: Gender specific investigations were carried out in a dual approach. 18 PSO,14 PSA and 20 PSA/PSO patients, divided into similarly sized gender-specific groups, whose disease progression and clinical parameters were analyzed. In addition, whole blood samples of our PSO/PSA cohort (n=52) compared to age-matched healthy controls were isolated and sequenced to identify differences within transcriptome analysis via bulk RNA-Seq .Results: Clinical characterization revealed that female PSA/PSO patients have higher CRP values and lower PASI-Scores. Male PSA patients were significantly more likely to show axial involvement, described by inflammatory backpain or radiological evidence of sacroiliitis. PSO patients had higher PASI than PSA patients, across both sexes.Principal component analysis of gene expression profiles showed two distinct clusters driven by sex chromosomes. Pairwise comparison with age- and sex-matched controls revealed more female-specific than male-specific differentially expressed genes across all diseases.Conclusion: In conclusion, the main sex differences are the higher CRP levels, lower PASI-Scores and more axial involvement between PSA/PSO and PSA women and men. PSO patients had higher PASI-Scores. However, observations need to be further investigated and validated in a larger cohort. Nevertheless, our findings demonstrate the importance of individual and sex-depending diagnosis and therapy of PSO/PSA patients. The future goal is to find links between the various characteristics of psoriasis/psoriatic arthritis and the expression of different genes for different immune related pathways in order to develop new targeted therapeutic approaches and identifying biomarkers.Disclosures: The authors declare no conflicts of interest.Figure 1 Tarannum S Leung YY Johnson SR Widdifield J Strand V Rochon P Eder L Sex- and gender-related differences in psoriatic arthritis 2022 Nat Rev Rheumatol 513-26 Tarannum S, Leung YY, Johnson SR, Widdifield J, Strand V, Rochon P, Eder L. Sex- and gender-related differences in psoriatic arthritis. Nat Rev Rheumatol. 2022 Sep;18(9):513-26. DOI: 10.1038/s41584-022-00810-7 https://doi.org/10.1038/s41584-022-00810-7 Wierczeiko A Boegel S Möckel T Gaidies T Staubach-Renz P Philipp W Mohit N Staubach-Renz P Gerber S Schwarting A Sex-specific expression of immune-related genes in a cohort of psoriasis and psoriatic arthritis patients [under review] Wierczeiko A, Boegel S, Möckel T, Gaidies T, Staubach-Renz P, Philipp W, Mohit N, Staubach-Renz P, Gerber S, Schwarting A. Sex-specific expression of immune-related genes in a cohort of psoriasis and psoriatic arthritis patients [under review]. 0
1 1 Figure 1: Example of preliminary results of differential gene expression between sexes
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