25rhk013
10.3205/25rhk013
urn:nbn:de:0183-25rhk0136
Meeting Abstract
Resting heart rate as a prognostic marker for fatigue in Primary Sjoegren’s syndrome
Rohling Guisoni Mendes
Rohling Guisoni Mendes
Daniel
D
University of Lübeck, Department of Rheumatology and Clinical Immunology, Lübeck
author
Graßhoff
Graßhoff
Hanna
H
University of Lübeck, Department of Rheumatology and Clinical Immunology, Lübeck
author
Fourlakis
Fourlakis
Konstantinos
K
University of Lübeck, Department of Rheumatology and Clinical Immunology, Lübeck
author
Witt
Witt
Pia
P
University of Lübeck, Department of Rheumatology and Clinical Immunology, Lübeck
author
Steffen
Steffen
Alexandra
A
University of Lübeck, Department of Rheumatology and Clinical Immunology, Lübeck
author
Lottmann
Lottmann
Steffen
S
University of Lübeck, Department of Rheumatology and Clinical Immunology, Lübeck
author
Cantzler
Cantzler
Ernst Joseph
EJ
University of Lübeck, Department of Rheumatology and Clinical Immunology, Lübeck
author
Eichlohn
Eichlohn
Felicitas
F
University of Lübeck, Department of Rheumatology and Clinical Immunology, Lübeck
author
Leiber
Leiber
Marieke
M
University of Lübeck, Department of Rheumatology and Clinical Immunology, Lübeck
author
Stenger
Stenger
Sarah
S
University of Lübeck, Department of Rheumatology and Clinical Immunology, Lübeck
author
Riemekasten
Riemekasten
Gabriela
G
University of Lübeck, Department of Rheumatology and Clinical Immunology, Lübeck
author
Franzen
Franzen
Klaas
K
University of Lübeck, Department of Medical Clinic III, Lübeck
author
Lange
Lange
Tanja
T
University of Lübeck, Department of Rheumatology and Clinical Immunology, Lübeck
author
German Medical Science GMS Publishing House
Düsseldorf
610
20250917
engl
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung).
M0627
013
Deutsche Gesellschaft für Rheumatologie
Deutsche Gesellschaft für Orthopädische Rheumatologie
53. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 39. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
Deutscher Rheumatologiekongress 2025
Digitale Rheumatologie
Wiesbaden
20250917
20250920
DR.07
TextIntroduction: Fatigue affects approximately 70% of patients with primary Sjögren syndrome (pSS) and significantly impacts their quality of life . Notably, improvements in VO2max, a marker of cardiorespiratory fitness, appear to be associated with reductions in fatigue . Photoplethysmography (PPG) sensor technology has been shown to accurately measure resting heart rate (RHR) – a validated population-level biomarker of cardiorespiratory fitness . While a single RHR measurement provides limited information, PPG-based wearables allow continuous monitoring, with longitudinal data serving as a valuable prognostic marker . The study aimed to investigate the correlation between fatigue scores and RHR in pSS patients.Methods: Eight pSS patients and seven healthy controls were recruited over six months. Heart rate was measured using the wireless VitalPatch® PPG-sensor, and fatigue was assessed using the FACIT-F questionnaire . Participants wore the sensor for seven consecutive days as part of their daily lives. After the technology use period, the sensor and completed questionnaire were returned to our clinic. An in-house R script was developed to automate both the visualization and computation of resting heart rate data.Results: Patients with pSS demonstrated a higher mean RHR compared to healthy controls (62.6 ± 1.84 bpm vs. 56.1 ± 3.03 bpm). The minimum RHR in the pSS group was 57 bpm, whereas the healthy controls reached as low as 46 bpm, suggesting that pSS patients may maintain a higher heart rate even at rest. The FACIT-F scores indicated a mean of 33.4 ± 7.82 for pSS patients, compared to a higher mean score of 48.7 ± 3.59 in controls (lower FACIT-F scores indicate higher fatigue). No significant correlation between fatigue scores and RHR was found (p=0.098).Conclusion: pSS patients demonstrated a significantly higher RHR compared to healthy controls. Continuous, high-quality heart rate data collected via a PPG-based wearable device highlight the potential use of RHR as a non-invasive clinical marker of cardiovascular health in pSS patients. Further recruitment is required to better understand the relationship between fatigue levels and RHR in this population.Abbreviations: pSS: primary Sjoegren Syndrome RHR: Resting heart rate FACIT-F: Functional Assessment of Chronic Illness Therapy – Fatigue VO2max: maximal oxygen intake PPG: photoplethysmography
Mæland E
Miyamoto ST
Hammenfors D
Valim V
Jonsson MV
Understanding Fatigue in Sjögren's Syndrome: Outcome Measures, Biomarkers and Possible Interventions
2021
Front Immunol
703079
Mæland E, Miyamoto ST, Hammenfors D, Valim V, Jonsson MV. Understanding Fatigue in Sjögren's Syndrome: Outcome Measures, Biomarkers and Possible Interventions. Front Immunol. 2021 Jun 25;12:703079. DOI: 10.3389/fimmu.2021.703079
http://dx.doi.org/10.3389/fimmu.2021.703079
Miyamoto ST
Lendrem DW
Ng WF
Hackett KL
Valim V
Managing fatigue in patients with primary Sjögren's syndrome: challenges and solutions
2019
Open Access Rheumatol
77-88
Miyamoto ST, Lendrem DW, Ng WF, Hackett KL, Valim V. Managing fatigue in patients with primary Sjögren's syndrome: challenges and solutions. Open Access Rheumatol. 2019 Apr 24;11:77-88. DOI: 10.2147/OARRR.S167990
http://dx.doi.org/10.2147/OARRR.S167990
Gonzales TI
Jeon JY
Lindsay T
Westgate K
Perez-Pozuelo I
Hollidge S
Wijndaele K
Rennie K
Forouhi N
Griffin S
Wareham N
Brage S
Resting heart rate is a population-level biomarker of cardiorespiratory fitness: The Fenland Study
2023
PLoS One
e0285272
Gonzales TI, Jeon JY, Lindsay T, Westgate K, Perez-Pozuelo I, Hollidge S, Wijndaele K, Rennie K, Forouhi N, Griffin S, Wareham N, Brage S. Resting heart rate is a population-level biomarker of cardiorespiratory fitness: The Fenland Study. PLoS One. 2023 May 11;18(5):e0285272. DOI: 10.1371/journal.pone.0285272
http://dx.doi.org/10.1371/journal.pone.0285272
Quer G
Gouda P
Galarnyk M
Topol EJ
Steinhubl SR
Inter- and intraindividual variability in daily resting heart rate and its associations with age, sex, sleep, BMI, and time of year: Retrospective, longitudinal cohort study of 92,457 adults
2020
PLoS One
e0227709
Quer G, Gouda P, Galarnyk M, Topol EJ, Steinhubl SR. Inter- and intraindividual variability in daily resting heart rate and its associations with age, sex, sleep, BMI, and time of year: Retrospective, longitudinal cohort study of 92,457 adults. PLoS One. 2020 Feb 5;15(2):e0227709. DOI: 10.1371/journal.pone.0227709
http://dx.doi.org/10.1371/journal.pone.0227709
Cella D
Lai JS
Stone A
Self-reported fatigue: one dimension or more? Lessons from the Functional Assessment of Chronic Illness Therapy--Fatigue (FACIT-F) questionnaire
2011
Support Care Cancer
1441-50
Cella D, Lai JS, Stone A. Self-reported fatigue: one dimension or more? Lessons from the Functional Assessment of Chronic Illness Therapy--Fatigue (FACIT-F) questionnaire. Support Care Cancer. 2011 Sep;19(9):1441-50. DOI: 10.1007/s00520-010-0971-1
http://dx.doi.org/10.1007/s00520-010-0971-1
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