26dkou208
10.3205/26dkou208
urn:nbn:de:0183-26dkou2083
Meeting Abstract
Autologous chondrocyte implantation with spheroids of human autologous matrix-associated chondrocytes for femoroacetabular cam impingement-related acetabular cartilage defects yields similar clinical but superior radiological outcomes compared with bone marrow-stimulated debridement
El Kayali
El Kayali
Moses Kamal Dieter
MKD
Charité – Universitätsmedizin Berlin, Berlin, Deutschland
author
Stavros
Stavros
Goumenos
G
Charité – Universitätsmedizin Berlin, Berlin, Deutschland
author
Olga
Olga
Pidgaiska
P
Charité – Universitätsmedizin Berlin, Berlin, Deutschland
author
Stöckle
Stöckle
Ulrich
U
Charité – Universitätsmedizin Berlin, Berlin, Deutschland
author
Paksoy
Paksoy
Alp
A
Charité – Universitätsmedizin Berlin, Berlin, Deutschland
author
Meller
Meller
Sebastian
S
Charité – Universitätsmedizin Berlin, Berlin, Deutschland
author
German Medical Science GMS Publishing House
Düsseldorf
610
20261020
engl
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung).
M0659
208
Deutsche Gesellschaft für Orthopädie und Unfallchirurgie
Deutsche Gesellschaft für Orthopädie und Orthopädische Chirurgie
Deutsche Gesellschaft für Unfallchirurgie
Berufsverband für Orthopädie und Unfallchirurgie
Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2026)
Abstracts | Impingement
Berlin
20261020
20261023
DKOU26_Abs_2438
TextObjectives and questions: Autologous chondrocyte implantation (ACI) using spheroids of human autologous matrix-associated chondrocytes is an established treatment for focal cartilage defects, but evidence for its use in the hip remains limited. For CAM-type femoroacetabular impingement (CAM-FAI), acetabular cartilage lesions can also be managed with bone-marrow–stimulated debridement (BMSD). This study compared the clinical and radiological outcomes of ACI with chondrosphere implantation versus BMSD for the treatment of CAM-FAI–related acetabular cartilage defects.Material and methods: This matched-pair study retrospectively identified adult patients treated with either ACI using spheroids of autologous matrix-associated chondrocytes (CO.DON AG) or BMSD for CAM-FAI–associated acetabular cartilage defects and prospectively evaluated them at a follow-up ≥2 years post-treatment. A 1:1 matched-pair design was applied using strict matching criteria. Clinical outcomes included iHOT-33, mHHS, HOOS, and VAS pain. Radiological outcomes were assessed by MRI using the MOCART score. Descriptive and matched-pair statistical analyses were performed.Results: A total of 31 (5/31 females) matched patient pairs (62 patients) were included in the analysis. The mean age at treatment was 34 ± 10 years in the ACI group and 35 ± 12 years in the BMSD group, and the mean follow-up interval was 7.8 ± 1.8 and 8.2 ± 1.7 years, respectively. Mean defect size measured 5.1 ± 0.9 cm² in the ACI group and 4.2 ± 1.3 cm² in the BMSD group. iHOT-33, mHHS, HOOS, and VAS pain scores did not differ statistically between ACI and BMSD. MRI evaluation indicated superior cartilage repair quality after ACI. MOCART scores were 80 ± 15 for ACI and 50 ± 15 for BMSD (p < 0.001).Discussion and conclusions: ACI and BMSD resulted in comparable clinical outcomes, but MRI findings indicated superior cartilage repair quality after ACI. These results suggest a potential structural advantage of ACI, warranting longitudinal studies to evaluate its impact on cartilage preservation and osteoarthritis progression.
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