26dkou138 10.3205/26dkou138 urn:nbn:de:0183-26dkou1382 Meeting Abstract Zhang Zhang Huanglin H

Department of Orthopaedics, Trauma and Reconstructive Surgery, University Hospital RWTH Aachen, Aachen, Deutschland

author Roth Roth Sabine S

Department of Orthopaedics, Trauma and Reconstructive Surgery, University Hospital RWTH Aachen, Aachen, Deutschland

author Bläsius Bläsius Felix F

Department of Orthopaedics, Trauma and Reconstructive Surgery, University Hospital RWTH Aachen, Aachen, Deutschland

author Nikody Nikody Martyna M

Experimental Orthopaedics and Trauma Surgery, University Hospital RWTH Aachen, Aachen, Deutschland

author Che Che Zhen Z

Experimental Orthopaedics and Trauma Surgery, University Hospital RWTH Aachen, Aachen, Deutschland

author Groven Groven Rald V. M. RVM

Department of Orthopaedics, Trauma and Reconstructive Surgery, University Hospital RWTH Aachen, Aachen, Deutschland

author Marzi Marzi Ingo I

Department of Trauma Surgery and Orthopedics, University Hospital, Goethe University Frankfurt, Frankfurt, Deutschland

author Vollrath Vollrath Tillmann T

Department of Trauma Surgery and Orthopedics, University Hospital, Goethe University Frankfurt, Frankfurt, Deutschland

author Rosado Balmayor Rosado Balmayor Elizabeth E

Experimental Orthopaedics and Trauma Surgery, University Hospital RWTH Aachen, Aachen, Deutschland

author Horst Horst Klemens K

Department of Trauma-, Hand- and Reconstructive Surgery, University Hospital Münster, Münster, Deutschland

author Hildebrand Hildebrand Frank F

Department of Orthopaedics, Trauma and Reconstructive Surgery, University Hospital RWTH Aachen, Aachen, Deutschland

author German Medical Science GMS Publishing House

Düsseldorf

610 20261020 engl This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). M0659 138 Deutsche Gesellschaft für Orthopädie und Unfallchirurgie Deutsche Gesellschaft für Orthopädie und Orthopädische Chirurgie Deutsche Gesellschaft für Unfallchirurgie Berufsverband für Orthopädie und Unfallchirurgie Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2026) Abstracts | Polytrauma Berlin 20261020 20261023 DKOU26_Abs_2360 TextObjectives and questions: Polytrauma (PT) triggers complex immune responses that contribute to organ crosstalk and post-traumatic inflammatory complications. Circulating biomarkers may reflect trauma severity as well as post-traumatic immune responses, yet their dynamic behavior and clinical relevance across different trauma severities remain not fully understood.Material and methods: In this multicenter prospective study, patients (n=87) were prospectively included into two groups; PT without chest trauma (PT-; n = 43) or PT with chest trauma (PT+; n = 44). Serum samples were collected at six consecutive timepoints; at admission and at 8, 24, and 48 hr, and 5 and 10 d after trauma. Nine predefined circulating biomarkers related to the post-traumatic immune response, chemotaxis, and tissue regeneration were quantified using ELISA. Cross-sectional comparisons, longitudinal mixed-effects models, correlation analyses, and multivariable linear regression were performed to evaluate associations with injury severity and Intensive Care Unit length of stay (ICU-LOS).Results: Several biomarkers demonstrated significant trauma severity- and time-dependent expression patterns. In the acute post-traumatic phase (admission and 8 hr), levels of hepatocyte growth factor and macrophage migration inhibitory factor were increased in the PT+ group as compared to the PT-group. Furthermore, the expression of both interferon-γ–inducible protein 10 and C-C Motif Chemokine Ligand 5 showed to be dependent on trauma severity as well as the time after trauma. Although multiple biomarkers were correlated with ICU-LOS in univariate analyses, none independently predicted ICU-LOS after adjustment for the Injury Severity Score.Discussion and conclusions: Polytrauma with concomitant chest trauma resulted in unique inflammatory marker profiles in the systemic circulation. Furthermore, several of the analyzed biomarker candidates showed trauma severity as well as time dependent circulating expression levels. This study demonstrated the relevance of dynamic biomarker monitoring over time to provide greater insight into immune dysregulation and organ crosstalk compared to singular point-of-care measurements. While anatomical injury severity remains the primary determinant of ICU-LOS, integrating time-dependent biomarker expression profiles with established clinical scores may enhance risk stratification for post-traumatic inflammatory complications after severe trauma. 0 0 0 0