26doc110 10.3205/26doc110 urn:nbn:de:0183-26doc1108 Meeting Abstract Kovalov Kovalov Ivan I

AILAS Medical Center, Ophthalmology, Kyiv, Ukraine

author Shargorodska Shargorodska Irina I

Bogomolets National Medical University, Ophthalmology, Kyiv, Ukraine

author Averyanova Averyanova Oksana O

AILAS Medical Center, Ophthalmology, Kyiv, Ukraine

author Kovalov Kovalov Andriy A

AILAS Medical Center, Ophthalmology, Kyiv, Ukraine

author German Medical Science GMS Publishing House

Düsseldorf

610 20260617 engl This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). M0651 110 38. Internationaler Kongress der Deutschen Ophthalmochirurgie (DOC) Hornhaut Nürnberg 20260618 20260620 FP 10.11 TextPurpose: To compare the results of treatment of 2 groups of patients with the Central Form of Fuchs Endothelial Corneal Dystrophy, treated by Central Descemetorhexis (DSO or DWEK). Methods: Retrospective analysis of 2 groups of patients. Both groups were similar in age, sex, and severity of Dystrophy: Confluent guttae at central 4.0 – 5.5 mm, peripheral Endothelial Cells Count 1,200 – 2,200, with 45% – 65% of Hexagonal Cells. In both groups, DSO was a part of the Triple Procedure: Phaco + IOL implantation + DSO. First group: 12 eyes of 12 patients. The Descemetorhexis was performed using the standard method, starting with the formation of a Descemet membrane tear using a Reverse Sinski Hook. The second group: 8 eyes of 8 patients. The Descemetorhexis was formed by the “atraumatic” method. The Descemetorhexis was initiated at the Descemet membrane incision using the sharp side-port blade. The original instrument with the mushroom-shaped working head was used to atraumatically separate the Descemet membrane from the corneal stroma and to perform the Descemetorhexis. Standard postoperative treatment, including topical antibiotics, anti-inflammatories, hyperosmotic, and artificial tears, for both groups. Topical Rho Kinase (ROCK) Inhibitors were not certified in Ukraine and were not used. Follow up from 6 months to 3 years. Results: Restoration of a continuous endothelial cells layer (Re-Endothelization) with the normalization of stromal thickness, restoration of transparency, and the possibility of Central endothelial cells count (≤ 600+ Cells): 10 (out of 12) eyes from Group 1 Re-Endothelized. Mean time: 6.2 +/- 3.3 weeks. 2 eyes did not, and DMEK/DSAEK procedures were performed 6+ months after DSO. All 8 eyes in Group 2 were successfully Re-Endothelialized. Mean time: 4.3 +/- 3.8 weeks.Discussion: It is well known that an irregular stromal surface slows, or in extreme cases, prevents the migration of endothelial cells (Re-Endothelisation). Tearing the Descemet membrane by Reverse Sinski Hook inevitably traumatizes the inner surface of the corneal stroma. Thus, performing the DSO by using a standard method may slow the migration of Endothelial cells. Conclusions: In these 2 small groups of patients, performing an “atraumatic” DSO approach with the Descemet membrane incision as a starting point and using the original instrument with the mushroom-shaped working head seems beneficial for faster rehabilitation (Re-Endothelization). 0 0 0 0