26vzmnrw096
10.3205/26vzmnrw096
urn:nbn:de:0183-26vzmnrw0962
Meeting Abstract
Osteopenia predicts long-term survival in male patients undergoing minor liver resection for colorectal liver metastases
Belger
Belger
E.
E
Uniklinik RWTH Aachen, Klinik für Allgemein-, Viszeral-, Kinder- und Transplantationschirurgie, Aachen, Deutschland
author
Palzer
Palzer
J.
J
Uniklinik RWTH Aachen, Klinik für Allgemein-, Viszeral-, Kinder- und Transplantationschirurgie, Aachen, Deutschland
author
David
David
S.
S
Uniklinik RWTH Aachen, Klinik für Allgemein-, Viszeral-, Kinder- und Transplantationschirurgie, Aachen, Deutschland
author
Hitpass
Hitpass
L.
L
Uniklinik RWTH Aachen, Klinik für diagnostische und interventionelle Radiologie, Aachen, Deutschland
author
Siepmann
Siepmann
R.
R
Uniklinik RWTH Aachen, Klinik für diagnostische und interventionelle Radiologie, Aachen, Deutschland
author
Wirtz
Wirtz
T.
T
Uniklinik RWTH Aachen, Klinik für Gastroenterologie, Stoffwechselerkrankungen und Internistische Intensivmedizin, Aachen, Deutschland
author
Ramackers
Ramackers
W.
W
Uniklinik RWTH Aachen, Klinik für Allgemein-, Viszeral-, Kinder- und Transplantationschirurgie, Aachen, Deutschland
author
Beetz
Beetz
O.
O
Uniklinik RWTH Aachen, Klinik für Allgemein-, Viszeral-, Kinder- und Transplantationschirurgie, Aachen, Deutschland
author
Oldhafer
Oldhafer
F.
F
Uniklinik RWTH Aachen, Klinik für Allgemein-, Viszeral-, Kinder- und Transplantationschirurgie, Aachen, Deutschland
author
von Websky
von Websky
M.
M
Uniklinik RWTH Aachen, Klinik für Allgemein-, Viszeral-, Kinder- und Transplantationschirurgie, Aachen, Deutschland
author
Vogel
Vogel
T.
T
Uniklinik RWTH Aachen, Klinik für Allgemein-, Viszeral-, Kinder- und Transplantationschirurgie, Aachen, Deutschland
author
Vondran
Vondran
F.
F
Uniklinik RWTH Aachen, Klinik für Allgemein-, Viszeral-, Kinder- und Transplantationschirurgie, Aachen, Deutschland
author
Meister
Meister
F.
F
Uniklinik RWTH Aachen, Klinik für Allgemein-, Viszeral-, Kinder- und Transplantationschirurgie, Aachen, Deutschland
author
Amygdalos
Amygdalos
I.
I
Uniklinik RWTH Aachen, Klinik für Allgemein-, Viszeral-, Kinder- und Transplantationschirurgie, Aachen, Deutschland
author
German Medical Science GMS Publishing House
Düsseldorf
610
20260618
engl
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung).
M0644
096
Niederrheinisch-Westfälische Gesellschaft für Chirurgie
Gesellschaft für Gastroenterologie in Nordrhein-Westfalen e.V.
192. Jahrestagung der Niederrheinisch-Westfälischen Gesellschaft für Chirurgie, 34. Jahrestagung der Gesellschaft für Gastroenterologie
Viszeralmedizin NRW 2026
Chirurgie
Dortmund
20260618
20260619
096
TextBackground and objective: Changes in body composition have been associated with both perioperative and long-term outcomes following oncological procedures across various cancer entities. However, the potential predictive role of bone mineral density (BMD) in patients with colorectal liver metastases regarding perioperative outcomes and long-term survival remains unclear. The aim of this study was to investigate the role of BMD as a prognostic factor in patients undergoing surgery for colorectal liver metastases, specifically in relation to perioperative morbidity and long-term survival.Method: Consecutive patients who underwent curative-intent surgery for colorectal liver metastases at RWTH Aachen University Hospital between 2010 and 2021 were included in this retrospective analysis. BMD was measured using preoperative CT-based segmentation at the level of the 11th thoracic vertebra. Perioperative complications were stratified according to the Clavien–Dindo classification and the Comprehensive Complication Index (CCI). Explorative receiver-operating characteristic (ROC) analyses were conducted for complications and survival endpoints, defining cut-off values for osteopenia through area-under-the-curve (AUC) measurements and Youden Index assessment. Survival outcomes were compared using Kaplan-Meier curves and the log-rank test, while independent risk factors were identified using Cox-regression analysis.Result: In the explorative analysis of 550 patients operated within the defined time period, BMD demonstrated good predictive ability for 3-year (AUC=0.755, p= 0.001), 5-year (AUC=0.753, p<0,001) and 10-year (AUC=0.749, p<0,001) mortality in male patients with synchronous liver metastases undergoing minor liver resection (n=74). Osteopenia in this subgroup was defined as BMD<130.135 HU and osteopenic patients (n=28, 37.84%) exhibited significantly higher 3-year (53.6% vs. 13%, p<0.001), 5-year (67.9% vs. 19.6%, p<0.001) and 10-year (71.4% vs. 21.7%, p<0.001) mortality compared with non-osteopenic patients. Osteopenia was an independent risk factor for reduced OS in the mentioned cohort (HR: 2.591; 95% CI: [1.018-6.598]; p=0.046). No significant differences in perioperative complications were observed.Summary: This study demonstrates that osteopenia is an independent predictor of inferior survival in male patients with synchronous liver metastases undergoing minor liver resection. Further research is needed to validate these results.
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