25rg33
10.3205/25rg33
urn:nbn:de:0183-25rg338
Meeting Abstract
Structural and microvascular retinal changes as biomarkers for cognitive impairment and fatigue symptoms in multiple sclerosis disease
Abdin
Abdin
Alaa Din
AD
Homburg/Saar
author
Yordanov
Yordanov
V.
V
Homburg/Saar
author
Fousse
Fousse
M.
M
Klinik für Neurologie, Homburg/Saar
author
Groppa
Groppa
S.
S
Klinik für Neurologie, Homburg/Saar
author
Seitz
Seitz
B.
B
Homburg/Saar
author
German Medical Science GMS Publishing House
Düsseldorf
610
20250613
engl
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung).
M0622
33
Retinologische Gesellschaft
37. Jahrestagung der Retinologischen Gesellschaft
CCS/Varia
Berlin
20250627
20250628
25rg33
TextPurpose: To assess the structural and microvascular chorioretinal changes in patients with multiple sclerosis (MS). We also investigated whether these changes correlate with the severity of fatigue and cognitive impairment in patients with MS.Patients and Methods: This prospective study included 77 patients with confirmed MS and 30 healthy, age-matched control subjects. All participants underwent both optical coherence tomography (OCT) and OCT angiography (OCTA) with enhanced depth of image (EDI). Outcome measures included: Best corrected visual acuity (BCVA), superficial capillary plexus vessel density (VD), perfusion density (PFD), foveal avascular zone area (FAZ), retinal nerve fiber layer thickness (RNFL), retinal ganglion cell layer thickness (RGCL), central macular thickness (CMT), and subfoveal choroidal thickness (SFCT). The severity of the patients’ fatigue was determined using the Modified Fatigue Impact Scale (MFIS), while cognitive impairment was assessed using the Montreal Cognitive Assessment (MoCA) test.Results: Compared to control subjects, there were no significant differences in age, gender, BCVA and SFCT. However, MS patients showed significantly larger FAZ surface (0.25±0.13 vs 0.19±0.08 mm2, p=0.01), lower macular VD (18.1±3.5vs 19.2±5.1 mm/mm2, p=0.02) and PED (42.1±7.9 vs 44.5±4.5%, p=0.02), thinner RNFL in nasal subfields and thinner RGCL in all macular subfields. The MFIS showed a significant negative correlation with the superior perifoveal RGCL thickness, while the MoCA test showed a significant negative correlation with the foveal VD and PFD.Conclusions: Compared to healthy individuals, MS patients exhibited larger FAZ surface area, lower macular PED, along with thinner RGCL and nasal RNFL. In addition, higher perifoveal RGCL thickness might be correlated with less fatigue, while higher foveal perfusion density might be correlated with less cognitive impairment.
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