Sensitivity to interaural time differences as a function of age and shape of acoustic stimuli in normal hearing humans

25dga015 10.3205/25dga015 urn:nbn:de:0183-25dga0156 Meeting Abstract Sensitivity to interaural time differences as a function of age and shape of acoustic stimuli in normal hearing humans Lucas Lucas Celestine C

author Wiebe Wiebe Konstantin K

Universitätsklinikum Freiburg, Fakultät für Medizin, Klinik für Hals-, Nasen- und Ohrenheilkunde, Sektion Cochlear Implant, Freiburg, Deutschland

author Schnupp Schnupp Jan W. JW

Chinese University of Hong Kong, Gerald Choa Neuroscience Institute, Hong Kong, Hong Kong Chinese University of Hong Kong, Department of Otolaryngology, Hong Kong, Hong Kong

author Arndt Arndt Susan S

Universitätsklinikum Freiburg, Fakultät für Medizin, Klinik für Hals-, Nasen- und Ohrenheilkunde, Sektion Experimentell-klinische Otologie, Freiburg, Deutschland

author Wesarg Wesarg Thomas T

Universitätsklinikum Freiburg, Fakultät für Medizin, Klinik für Hals-, Nasen- und Ohrenheilkunde, Sektion Cochlear Implant, Freiburg, Deutschland Universitätsklinikum Freiburg, Fakultät für Medizin, Klinik für Hals-, Nasen- und Ohrenheilkunde, Sektion Experimentell-klinische Otologie, Freiburg, Deutschland

author Rosskothen-Kuhl Rosskothen-Kuhl Nicole N

Universitätsklinikum Freiburg, Fakultät für Medizin, Klinik für Hals-, Nasen- und Ohrenheilkunde, Sektion Experimentell-klinische Otologie, Neurobiologisches Forschungslabor, Freiburg, Deutschland Universität Freiburg, Bernstein Center Freiburg, Fakultät für Biologie, Freiburg, Deutschland

author German Medical Science GMS Publishing House

Düsseldorf

610 20250318 engl This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). M0607 015 Deutsche Gesellschaft für Audiologie e. V. und ADANO 27. Jahrestagung der Deutschen Gesellschaft für Audiologie und Arbeitstagung der Arbeitsgemeinschaft Deutschsprachiger Audiologen, Neurootologen und Otologen Freie Vorträge 1: Experimentelle Otologie Göttingen 20250319 20250321 015 TextHorizontal sound localization is based on two important binaural cues: interaural time differences (ITDs) and interaural level differences (ILDs). In normal hearing (NH) adults, the ITD sensitivity threshold at 250 Hz is around 25–30 µs . However, the sensitivity to binaural cues can be influenced by various factors such as hearing experience, developmental state or the type of the acoustic stimulus , , . The development of ITD sensitivity across age and its dependency on stimulus parameters are still under research and were investigated in this study.Eleven NH (<20 dB HL) children (Ø 9.05 years old) and 10 NH adults (Ø 34.03 years old) were tested on sound lateralization in a gamified setup using headphones. A 0.5 s long tone burst at 250 Hz and a rising slope of 4 ms or 100 ms was used as acoustic stimulus. Participants were tested for different ITDs of ±\'7b25, 50, 100, 200, 400, 800\'7d µs. ITD just-noticeable differences (JNDs) were calculated for the different test conditions using psychometric functions.NH adults demonstrated significantly better ITD JNDs (Ø 64.79 µs) compared to NH children (Ø 93.61 µs) for both slope conditions. For NH children, ITD sensitivity showed a positive correlation with age under both test conditions, indicating developmental improvement. Notably, both cohorts exhibited significantly better ITD JNDs when the auditory stimuli were presented with a rising slope of 4 ms (children: Ø 92.07 µs, adults: Ø 55.78 µs) rather than 100 ms (children: Ø 113.89 µs, adults: Ø 73.28 µs).In conclusion, auditory networks for ITD-based spatial hearing are still maturing in early childhood [DTW1] , resulting in significantly poorer ITD sensitivity compared to mature, adult networks. Regardless of developmental stage, better ITD sensitivity was achieved with auditory stimuli that contained strong onset ITD information (4 ms rising slope), confirming the importance of onset ITD sensitivity for optimal spatial hearing. Zwislocki J Feldman RS Just Noticeable Dichotic Phase Difference 1956 J Acoust Soc Am 152-3 Zwislocki J, Feldman RS. Just Noticeable Dichotic Phase Difference. J Acoust Soc Am. 1956;28:152-3. Greenberg D Monaghan JJM Dietz M Marquardt T McAlpine D Influence of envelope waveform on ITD sensitivity of neurons in the auditory midbrain 2017 J Neurophysiol 2358-70 Greenberg D, Monaghan JJM, Dietz M, Marquardt T, McAlpine D. Influence of envelope waveform on ITD sensitivity of neurons in the auditory midbrain. J Neurophysiol. 2017 Oct 1;118(4):2358-70. DOI: 10.1152/jn.01048.2015 http://dx.doi.org/10.1152/jn.01048.2015 Syeda A Nisha KV Jain C Age differences in binaural and working memory abilities in school-going children 2023 Int J Pediatr Otorhinolaryngol 111652 Syeda A, Nisha KV, Jain C. Age differences in binaural and working memory abilities in school-going children. Int J Pediatr Otorhinolaryngol. 2023 Aug;171:111652. DOI: 10.1016/j.ijporl.2023.111652 http://dx.doi.org/10.1016/j.ijporl.2023.111652 Thavam S Dietz M Smallest perceivable interaural time differences 2019 J Acoust Soc Am 458 Thavam S, Dietz M. Smallest perceivable interaural time differences. J Acoust Soc Am. 2019 Jan;145(1):458. DOI: 10.1121/1.5087566 http://dx.doi.org/10.1121/1.5087566 0 0 0 0