25dga011 10.3205/25dga011 urn:nbn:de:0183-25dga0110 Meeting Abstract Heeringa Heeringa Amarins A

Carl von Ossietzky Universität Oldenburg, Department for Neuroscience, Oldenburg, Deutschland

author German Medical Science GMS Publishing House

Düsseldorf

610 20250318 engl This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). M0607 011 Deutsche Gesellschaft für Audiologie e. V. und ADANO 27. Jahrestagung der Deutschen Gesellschaft für Audiologie und Arbeitstagung der Arbeitsgemeinschaft Deutschsprachiger Audiologen, Neurootologen und Otologen Strukturierte Sitzung 4: Mechanismen der Schallempfindungsschwerhörigkeit Göttingen 20250319 20250321 011 TextAuditory nerve fibers typically show a large variety of spontaneous rates, ranging from 0 to up to 200 spikes/s. This spontaneous rate correlates with the fiber’s sound encoding features, such as rate threshold, first-spike latency, and phase locking. It is believed that this underlies the large dynamic range of the auditory nerve for encoding rich acoustic environments. In this study, spikes of auditory nerve fibers were recorded from young-adult and old Mongolian gerbils. In the gerbil, known for its good low-frequency hearing, the distribution of spontaneous rate, and thus also of the response features, differs between low- and high-frequency regions of the cochlea. Here, I will show how ageing affects the auditory nerve fiber functional heterogeneity along the gerbil cochlea and which age-related degenerative processes in the cochlea can explain these results. 0 0 0 0