25vzmnrw66 10.3205/25vzmnrw66 urn:nbn:de:0183-25vzmnrw661 Meeting Abstract Loosen Loosen Sven S

Universitätsklinikum Düsseldorf, Düsseldorf, Deutschland

author Essing Essing Tobias T

Universitätsklinikum Düsseldorf, Düsseldorf, Deutschland

author Mertens Mertens Alexander A

Universitätsklinikum Düsseldorf, Düsseldorf, Deutschland

author Loosen Loosen Sven S

Universitätsklinikum Düsseldorf, Düsseldorf, Deutschland

author Roderburg Roderburg Christoph C

Universitätsklinikum Düsseldorf, Düsseldorf, Deutschland

author Luedde Luedde Tom T

Universitätsklinikum Düsseldorf, Düsseldorf, Deutschland

author Kandler Kandler Jennis J

Universitätsklinikum Düsseldorf, Düsseldorf, Deutschland

author German Medical Science GMS Publishing House

Düsseldorf

610 20250530 engl This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). M0616 66 Niederrheinisch-Westfälische Gesellschaft für Chirurgie Gesellschaft für Gastroenterologie in Nordrhein-Westfalen e.V. 191. Jahrestagung der Niederrheinisch-Westfälischen Gesellschaft für Chirurgie, 33. Jahrestagung der Gesellschaft für Gastroenterologie Viszeralmedizin NRW 2025 Gastroenterologie Essen 20250612 20250613 66 TextBackground: Endoscopic papillectomy (EP) is a minimally invasive procedure for the resection of early ampullary neoplasia. While it is increasingly being adopted as an alternative to surgical resection, the outcomes and complication rates associated with EP vary across different settings and patient populations. However, data on recent clinical developments, as well as a reliable determination of hospital mortality following EP in Germany, remain lacking.Methods: Clinical trends and hospital mortality of EP in Germany between 2018 and 2022 were analyzed based on standardized hospital discharge data from the Federal Statistical Office of Germany.Results: A total of 3366 EPs were performed in Germany between 2018 and 2022. The annual number of EPs significantly increased from 557 cases in 2018 to 750 cases in 2022. The median duration of hospitalization was 8.71 days. Hospital mortality was 1.75% and numerically higher in female patients (2.0%) and patients above 70 years (2.2%). Bleeding (16.8%) and post-EP pancreatitis (PEPP, 13.2%) were the most common complications. Among others, the need for mechanical ventilation (42.5%), acute renal failure (21.5%), and biliary/duodenal perforations (17.6/13.5%) were identified as the main factors associated with increased mortality. Prophylactic stenting of the main pancreatic duct (MPD) was not associated with reduced rates of PEPP (13.31 vs. 13.12%) but revealed a non-significant trend towards a lower hospital mortality (1.40 vs. 1.95%, p=0.236). Conclusion: EP is increasingly performed in Germany. It is a highly effective albeit complex procedure with relatively high procedure related risks and a hospital mortality rate of 1.75%, which is slightly higher than previously described, but still relatively low compared to invasive surgery. However, several complications associated with poor outcomes were identified, which could help improve patient selection and optimize peri- and post-interventional clinical decision-making to further reduce unfavorable outcomes in the future. 0 0 0 0