25dkou466
10.3205/25dkou466
urn:nbn:de:0183-25dkou4663
Meeting Abstract
Improving osseointegration of high-performance oxide ceramics through peptide surface coatings: Findings from an in vivo rabbit bone defect model
Groven
Groven
Rald
R
Department of Orthopedic, Trauma- and Reconstructive Surgery, RWTH Aachen University Hospital, Aachen, Deutschland
Experimental Orthopedics and Trauma Surgery, RWTH Aachen University Hospital, Aachen, Deutschland
author
Qi
Qi
Changlin
C
Experimental Orthopedics and Trauma Surgery, RWTH Aachen University Hospital, Aachen, Deutschland
author
Schräder
Schräder
Philipp
P
Department of Dental Materials and Biomaterials Research, RWTH Aachen University Hospital, Aachen, Deutschland
author
Özman
Özman
Deniz
D
Department of Dental Materials and Biomaterials Research, RWTH Aachen University Hospital, Aachen, Deutschland
author
Zhao
Zhao
Qun
Q
Experimental Orthopedics and Trauma Surgery, RWTH Aachen University Hospital, Aachen, Deutschland
author
Labude-Weber
Labude-Weber
Norina
N
Helmholtz Institute for Biomedical Engineering, Biointerface Group, RWTH Aachen University Hospital, Aachen, Deutschland
author
Hildebrand
Hildebrand
Frank
F
Department of Orthopedic, Trauma- and Reconstructive Surgery, RWTH Aachen University Hospital, Aachen, Deutschland
author
Neuss-Stein
Neuss-Stein
Sabine
S
Helmholtz Institute for Biomedical Engineering, Biointerface Group, RWTH Aachen University Hospital, Aachen, Deutschland
Institute of Pathology, RWTH Aachen University Hospital, Aachen, Deutschland
author
Fischer
Fischer
Horst
H
Department of Dental Materials and Biomaterials Research, RWTH Aachen University Hospital, Aachen, Deutschland
author
Rosado Balmayor
Rosado Balmayor
Elizabeth
E
Experimental Orthopedics and Trauma Surgery, RWTH Aachen University Hospital, Aachen, Deutschland
author
Schenker
Schenker
Hanno
H
Department of Orthopedic, Trauma- and Reconstructive Surgery, RWTH Aachen University Hospital, Aachen, Deutschland
author
German Medical Science GMS Publishing House
Düsseldorf
610
20251031
engl
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung).
M0634
466
Deutsche Gesellschaft für Orthopädie und Unfallchirurgie
Deutsche Gesellschaft für Orthopädie und Orthopädische Chirurgie
Deutsche Gesellschaft für Unfallchirurgie
Berufsverband für Orthopädie und Unfallchirurgie
Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2025)
Abstracts | Gelenkersatz – perioperativ
Berlin
20251028
20251031
AB73-4304
TextObjectives and questions: High-performance ceramics (HPOC) are used as articulating components in arthroplasty because of their high strength and wear resistance. However, their bioinert nature leads to poor osseointegration when placed in direct contact with bone, as e.g. in the case with all-ceramic knee implants. The aim of this study was to investigate the effect of a biological functionalization on the osseointegrative capabilities of HPOCs in vivo.Material and methods: The rabbit model consisted of three experimental groups: a control (untreated HPOC; n=8), a cRGD-coated (n=8), and a mod-HGF-coated group (n=8). Cylindrical defects measuring 4.5 x 6 mm were created in the lateral femoral epicondyle, after which the HPOC cylinders were press-fitted into the defect. After an 18-week observation period, animals were sacrificed and the distal femur was harvested for micro-computed tomography (CT) and histological staining (Safranin-O, Movat Pentachrom, H&E, and Giemsa).Results: Macroscopically, both the cRGD and the mod-HGF groups showed improved osteointegration of the implant as compared to the control group. Micro-CT imaging confirmed these macroscopic observations, with increased total bone volume and denser bone forming around the implant in both treatment groups compared to the control.Discussion and conclusions: Biological functionalization of HPOCs can improve osseointegration at the implant-bone interface, without causing excessive callus formation or heterotopic ossification in the immediate implant area. Micro-CT data showed increased bone density in both peptide surface coating groups as compared to control. These results show that organo-chemical functionalisation imparts bioactive properties to HPOC, resulting in improved bone bonding.
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