25rhk173 10.3205/25rhk173 urn:nbn:de:0183-25rhk1732 Meeting Abstract Dreher Dreher Matthias M

Department of Internal Medicine I, Division of Rheumatology and Clinical Immunology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz

author Hoschek Hoschek Jessika J

Department of Internal Medicine I, Division of Rheumatology and Clinical Immunology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz

author Boedecker-Lips Boedecker-Lips Simone Cosima SC

Department of Internal Medicine I, Department of Nephrology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz

author Weinmann-Menke Weinmann-Menke Julia J

Department of Internal Medicine I, Department of Nephrology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz

author Weinmann Weinmann Arndt A

Department of Internal Medicine I, University Medical Center of the Johannes Gutenberg University Mainz, Mainz

author Schwarting Schwarting Andreas A

Department of Internal Medicine I, Division of Rheumatology and Clinical Immunology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz Rheumatology Center Rhineland-Palatinate, Bad Kreuznach

author German Medical Science GMS Publishing House

Düsseldorf

610 20250917 engl This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). M0627 173 Deutsche Gesellschaft für Rheumatologie Deutsche Gesellschaft für Orthopädische Rheumatologie 53. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 39. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh) Deutscher Rheumatologiekongress 2025 Vaskulitiden & Kollagenosen Wiesbaden 20250917 20250920 VK.06 TextIntroduction: Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease characterized by multi-organ involvement, circulating autoantibodies, and relapsing-remitting progression. Effective management is particularly challenging for less experienced clinicians . The Mainz Lupus Score (MLS) was developed as a practical tool to support therapy management, emphasizing both objective measures and subjective patient-reported outcomes (PROs). This study aimed to evaluate the MLS by comparing its performance to established indices such as the SLEDAI, ECLAM, and SLICC, while also exploring correlations with subjective measures including the Fatigue Severity Scale (FSMC), Beck Depression Inventory (BDI) and Workability Index.Methods: Data from 458 SLE patients at the University Medical Center Mainz were analysed, including 93 patients with at least three visits and 422 visits in total. The MLS incorporates four items: new lupus symptoms, quality of life (QoL), laboratory abnormalities, and organ damage. Correlations between the MLS and established indices were assessed using Spearman correlation and Kruskal-Wallis tests. In order to proof the applicability of the MLS in daily clinically routine the MLS score was compared to medical doctor’s (MD) treatment between the all visits by a paired Wilcoxon Signed Rank Test focussing on the outcome remission.Results: Significant correlations were observed between the MLS and SLEDAI (r = 0.403), SLICC (r = 0.427), and ECLAM (r = 0.537; p < 0.0001). The MLS demonstrated strong associations with therapy escalation and remission rates, aligning with treat-to-target goals. Although correlations with subjective scores like FSMC, BDI and WAI were weak to moderate, the integration of PROs offered valuable insights for therapy adjustments. When testing the MLS during everyday clinical routine no significant difference in remission change (p = 0,9398) was found between MLS based and medical doctor’s (MD) based therapy desicion, reflecting the previous decision.Conclusion: The MLS provides a clinically practical and validated approach to managing SLE, balancing objective metrics with patient-centered evaluations. While effective in distinguishing disease states and guiding therapy, broader multicenter validation is recommended to enhance its applicability. Fanouriakis A Kostopoulou M Andersen J Aringer M Arnaud L Bae SC Boletis J Bruce IN Cervera R Doria A Dörner T Furie RA Gladman DD Houssiau FA Inês LS Jayne D Kouloumas M Kovács L Mok CC Morand EF Moroni G Mosca M Mucke J Mukhtyar CB Nagy G Navarra S Parodis I Pego-Reigosa JM Petri M Pons-Estel BA Schneider M Smolen JS Svenungsson E Tanaka Y Tektonidou MG Teng YO Tincani A Vital EM van Vollenhoven RF Wincup C Bertsias G Boumpas DT EULAR recommendations for the management of systemic lupus erythematosus: 2023 update 2024 Ann Rheum Dis 15-29 Fanouriakis A, Kostopoulou M, Andersen J, Aringer M, Arnaud L, Bae SC, Boletis J, Bruce IN, Cervera R, Doria A, Dörner T, Furie RA, Gladman DD, Houssiau FA, Inês LS, Jayne D, Kouloumas M, Kovács L, Mok CC, Morand EF, Moroni G, Mosca M, Mucke J, Mukhtyar CB, Nagy G, Navarra S, Parodis I, Pego-Reigosa JM, Petri M, Pons-Estel BA, Schneider M, Smolen JS, Svenungsson E, Tanaka Y, Tektonidou MG, Teng YO, Tincani A, Vital EM, van Vollenhoven RF, Wincup C, Bertsias G, Boumpas DT. EULAR recommendations for the management of systemic lupus erythematosus: 2023 update. Ann Rheum Dis. 2024 Jan 2;83(1):15-29. DOI: 10.1136/ard-2023-224762 http://dx.doi.org/10.1136/ard-2023-224762 0 0 0 0