25rhk141 10.3205/25rhk141 urn:nbn:de:0183-25rhk1419 Meeting Abstract Tiede Tiede Robin R

LMU University Hospital Munich, Department of Pneumology, Munich

author Reichenberger Reichenberger Frank F

Clinic of Pulmonary Medicine, Pneumology, Seefeld-Hechendorf Augustinum Hospital, Department of Pneumology, Munich

author Fischinger Fischinger Carina C

LMU University Hospital Munich, Department of Pneumology, Munich

author Schwaiblmair Schwaiblmair Martin M

University of Augsburg, Department of Internal Medicine I, Augsburg

author Meyer Meyer F. Joachim FJ

Lung Center (Bogenhausen-Harlaching), München Klinik GmbH, Lung Center, Munich

author Benedikter Benedikter Josef J

Lung Center (Bogenhausen-Harlaching), München Klinik GmbH, Lung Center, Munich

author Popp Popp Florian F

MVZ für Rheumatologie Dr. M. Welcker, Rheumatology, Munich-Planegg

author Dechant Dechant Claudia C

Section of Rheumatology, Sozialstiftung Bamberg, Bamberg

author Späthling-Mestekemper Späthling-Mestekemper Susanna S

Rheumapraxis München-Pasing, Munich

author Thürmel Thürmel Klaus K

Augustinum Hospital Munich, Department of Nephrology and Rheumatology, Munich

author Wahle Wahle Matthias M

Department of Rheumatology, Medical Clinic III, University Hospital Augsburg, Augsburg

author Waßmann Waßmann Sven S

Herzpraxis Pasing, Munich

author Kneidinger Kneidinger Nikolaus N

LMU University Hospital Munich, Department of Pneumology, Munich Medical University of Graz, Division of Pneumology and Internal Medicine, Graz

author Welcker Welcker Martin M

M.B.W.-Welcker GbR, Rheumatologie, Planegg

author German Medical Science GMS Publishing House

Düsseldorf

610 20250917 engl This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). M0627 141 Deutsche Gesellschaft für Rheumatologie Deutsche Gesellschaft für Orthopädische Rheumatologie 53. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 39. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh) Deutscher Rheumatologiekongress 2025 Rheumatoide Arthritis Wiesbaden 20250917 20250920 RA.18 TextIntroduction: Interstitial lung disease (ILD) is a leading cause of death in patients with rheumatoid disease (RA). Given the high prevalence of RA, a physician-independent screening is mandatory.Therefore, this study aimed to provide a patient-based, economical screening questionnaire for rheumatoid arthritis-associated interstitial lung disease (RA-ILD).Methods: A 26-item sum-score questionnaire on ILD-symptoms was evaluated, adapted, and validated in two steps. Multiple imputation handled missing data. In the first step, an item- and principal component analysis was performed using a multicenter approach in patients with ILD and healthy controls. McDonald’s omega was calculated as a measure of internal consistency. An independent t-test was executed to test for score differences. The effect size was estimated using Cohen’s d. In the second step, the questionnaire was validated by monocentrically recruited patients with ACPA (anti-citrullinated peptide antibodies) and RF (rheumatoid factor)-positive RA based on ACR criteria, without prior pulmonary examination. ILD was defined as an abnormal lung ultrasound of 14 intercostal spaces with an FVC or DLCO < 80% of the predicted value. Receiver Operating Characteristics (ROC), sensitivity, and specificity were calculated.Results: In step one, 174 patients with ILD (46% female, mean age 62 ± 13 years, mean score 39 (95%-CI[35;43]) and 67 healthy controls (49% female, mean age 59 ± 12 years; mean score 8 (95%-CI[4;12]) were recruited. A McDonald's omega of 0.93 indicated excellent internal consistency. The independent t-test revealed a significant score difference of 31 points (95%-CI[26;36]) associated with large effect size, t(85 358.44) = –11.71, p < 0.001, d = |1.36|. In step two, the questionnaire was validated on 105 patients (76% female, mean age 59 ± 12 years, mean disease duration 9 ± 6 years, mean score 14 (95%-CI[10;17]), 11 of whom (82% female, mean age 65 ± 8 years, mean disease duration 10 ± 5 years, mean score 18 (95%-CI[8;28])) were suspected of having RA-ILD. A cut-off score of 7.5 points resulted in a ROC, sensitivity and specificity of 0.58 (95%-CI[0.39;0.77]), 70.3% (95%-CI[43.5;92.4]), and 47.7% (95%-CI[39.0;59.0]).Conclusion: The questionnaire showed promising results as a physician-independent, free RA-ILD screening tool for daily clinical practice.Disclosures: Conflict of interest: RT: Boehringer Ingelheim, FR: Boehringer Ingelheim, CF: Boehringer Ingelheim, M: Boehringer Ingelheim & Roche, JM: None declared, JB: None declared, FP: Boehringer Ingelheim, CD: None declared, SSM: Boehringer Ingelheim, KT: None declared, MW: Boehringer Ingelheim, SW: None declared, NK: Boehringer Ingelheim, MW: Abbvie, BMS, Fresenius, Galapagos, Gilead, GSK, Hexal, Janssen, Johnson & Johnson, Medac, Mylan, Novartis, Sanofi-Aventis, UCB, Viatris, Boehringer Ingelheim, UCDFigure 1 Table 1 11

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